With Irwin not answering the phone, Billy's parents missing and Mandy saying she wants "Billy for dinner", Billy and Grim assume Mandy is a cannibal who ate Billy's parents and friends. Looking for proof, Billy and Grim find tiki figures and arrangements for a celebration in Mandy's backyard. Ultimately, it is revealed that they are just celebrating Billy's birthday. Still, Mandy burps out Irwin's glasses.

Nergal, the fiend from the center of the Earth, returns to the surface, emerging a carnival with him, trying once more to make friends. In the following, Billy tries to help Nergal make friends by being considerate, but Nergal fails to apply correctly his advice. When Nergal is told that Grim was forced to be Billy and Mandy's friend-slave, Nergal then decides to force the world to be his friends by turning them into dark beings similar to him. In the end, Nergal turns Billy, Mandy, Grim and even the viewer (thus breaking the fourth wall) into one before the episode ends.

Billy tells Grim to help him throw a surprise birthday party for Mandy. Then, a reluctant Grim helps Billy prepare a cake while keeping it a secret from Mandy. In the end, a somewhat surprised Mandy reveals that her birthday isn't for the next five months, something that Billy already knew about.

Billy is constantly provoked by a bully named Sperg and runs over to Grim for help.

After taking the Underworld's "Bad Book" from Grim, Billy becomes possessed by an evil entity. Then, Billy steals Grim's scythe, and uses it to open a portal to summon Yog-Sothoth. In consequence, Mandy calls for Hoss Delgado to battle Billy. It is revealed that the portal can only be sealed by throwing the book into it. As Billy eats the book, Mandy throws Billy himself into the portal, restoring everything to normal. Instants later, a portal opens up and Billy comes out and says they didn't want him there.

After watching Billy and Irwin play with their "Hokey Monsters" cards (parodying the Pokémon Trading Card Game), Grim makes the monsters come to life. Soon, all the other kids want their own cards to be real too, and the city is soon under attack by a multitude of Hokey Monsters. To put an end to the mayhem, Mandy draws her own card, Mandy's Monster, which defeats all the other monsters by turning them into toast.

Billy accidentally sets off a powerful stink bomb in Mandy's house and, while the house is being disinfected and fumigated, Mandy's family goes to live with Billy's. Billy and Mandy have a dispute over how to split Billy's room, prompting Grim to intervene. Mandy takes over the entire room, and imprisons Billy inside a brick wall with his mouth gagged by a dark red handkerchief.

After excluding Mandy from their board game Who Killed Who? for being a girl, Billy and Irwin mistakenly throw their dice into the backyard of a haunted house. Grim warns them about the ghost of Mrs. Doolin, a lady that lived there. Mandy dares to go inside to retrieve the dice, and she befriends Mrs. Doolin, who is alive and well, and who says that all the stories told about her (that anything that went beyond her fence into her garden never came back) are inventions from Grim, whom she beat long time ago at a staring contest. Fearing for Mandy's life, Billy also ventures into the house, but Mrs. Doolin and Mandy scare him away by posing as ghosts. It appears that Mrs. Doolin is in fact a ghost, and when she meant "beating Grim", it meant that she "beaten death".

When Billy, Mandy and Grim go to the beach, Grim falls in love with a goth woman named Malaria. Grim is having a good time with his girlfriend, but Mandy assures him that will change when he tells her that he is not human. In the following date, Grim demonstrates his supernatural powers while dancing and, as predicted, Malaria leaves in panic.

At school, Mandy rejects Irwin's invitation to go to the school dance with him. Billy introduces his foreign and mysterious, new friend, "Piff", and Mandy becomes desperate when she realizes that she has developed a crush on him. Mandy asks Grim to cut her heart out to stop being in love, but Grim has a better idea and gives Mandy a makeover. Piff gets a crush on Mandy, who takes the opportunity to brutally turn him down.

Billy takes a big egg found in Grim's trunk and hatches it expecting a duck. Instead, Jeff the Spider is born, who considers Billy his father. Despite Jeff trying to please Billy in any possible way, Billy is terrified of Jeff and wants him squished. The exterminator chose not to squish Jeff because he is a nice bug.

Billy is worried about failing an upcoming Math test, so Grim gives him a "bookworm", which will make him much smarter. Milkshakes, Billy's cat, eats the worm instead, and is forced to tutor Billy. Billy is still an idiot in the end.

Grim is upset after his favorite show, Atrocia's Late Night Atrocities, is cancelled. He goes to the TV station and using his powers, turns the studio into a creepier place and becomes the host of the Grim Show. Grim's success on TV is interrupted when Mandy tells him he has neglected to do her chores. Billy and Mandy go to the TV station and show embarrassing footage of Grim at home.

After being accidentally hit by Billy, Grim lands in a can of white paint in a remote convent. Due to his appearance, still with the can in his head, Grim is mistaken for "Sister Big Mamma" by little nuns. Grim has a great time with the friendly nuns, until Billy and Mandy come looking for him. When the nuns realize the truth about Grim they get angry at him, but also help him go back home by sending him flying away with another punch.

When Billy and Irwin exclude Mandy and Grim from helping them build a go-kart to enter the Annual Endsville Go-Kart Competition, the latter two decide to build their own. Billy-Irwin, and Mandy-Grim compete against Mindy, Sperg, and a mystery racer (Pud'n). Mindy gets stuck in highway traffic, Billy-Irwin's car is destroyed, Sperg and Grim mutually prevent each other from winning, and Pud'n wins in his little red wagon.

After missing on a school trip, Grim takes Billy, Mandy and Irwin to the "Halls of Time" for a tour. There, Billy and Irwin mess the hourglasses that symbolize each person's lifespan. When they leave, they accidentally leave their own hourglasses, including Grim's, upside down, resulting in the group getting younger as time passes. Grim allows the kids to disappear by going before birth, but he cannot restore his own hourglass to its correct position and he disappears too.