After having a nervous breakdown and leaving the house in the first episode, Billy's mother, Gladys, returns. She meets Grim again and, this time, she plans to destroy him once and for all. When Grim goes to the kitchen for a glass of water, Gladys attacks him and shatters his skeleton. In the end, Grim assures the kids that Gladys has won the battle but not the war.

With Irwin not answering the phone, Billy's parents missing and Mandy saying she wants "Billy for dinner", Billy and Grim assume Mandy is a cannibal who ate Billy's parents and friends. Looking for proof, Billy and Grim find tiki figures and arrangements for a celebration in Mandy's backyard. Ultimately, it is revealed that they are just celebrating Billy's birthday. Still, Mandy burps out Irwin's glasses.

It's Halloween, Billy, Mandy and Grim go trick-or-treating. Grim mistakes a woman for Atrocia, the host of the all-night Halloween marathon on TV and goes to talk to her. Upon looking at her face, Grim realizes his mistake; however, the woman mistakes Grim for her son, Gregory, and takes him home Gregory is now Grim, and does not have a stomach. At the same time, Billy mistakes Gregory for Grim and he and Mandy take him with them. In the end, Billy and Mandy take Gregory back to his mother and Grim goes back with them.

Billy and Irwin have been playing their favorite video game, Beasts and Barbarians, for three days non-stop. In an attempt to stop their video game addiction, Grim transports them all to a real-life version of the game. Seeing as Billy and Irwin are still doing good in their quest, Grim increases the difficulty by manipulating the traps himself. In the end, Billy, Mandy, and Grim return home escaping from a giant cyclops, while Irwin remains trapped.

Billy, Mandy, and Grim go to the museum on a school trip. There, they meet Hoss Delgado, self-appointed hunter of the paranormal, who upon spotting Grim, tries to eliminate him. Subsequently, Grim and Delgado engage in a fight. Finally, Delgado quits hunting Grim when he realizes Billy and Mandy control him. In the end, Delgado continues his own adventures and is seen fighting a werewolf.

While going to the shopping mall with Billy and Mandy, Grim spots the beautiful Eris, the goddess of discord and chaos, and tries to ask her out. However, Eris is not interested in the skinless Grim, but in the muscular Adonis. Then, Eris invites Mandy to join her in creating chaos using the Apple of Discord. Although initially they get along, Eris pulls a prank on Mandy, who subsequently tries to get revenge. In the end, Mandy fools Eris into thinking that Adonis is in the movie theater, and Eris accidentally kisses Grim.

Billy eats too much junk food that makes him feel sick. Grim prepares him a remedy using his granny's recipe, but this medicine makes a parasite to start growing in Billy's back, which Billy names Yap-yap. In the following, Billy and Yap-yap continue eating junk food, so Mandy suggest to use the antidote to the original remedy. Eventually, Yap-yap, now looking like a smaller version of Billy, detaches himself from Billy (which would have technically cured Billy without the need of him drinking the anitdote), and tries to escape from the antidote. In the end, Yap-yap drinks the antidote and is destroyed.

Billy is constantly provoked by a bully named Sperg and runs over to Grim for help.

After taking the Underworld's "Bad Book" from Grim, Billy becomes possessed by an evil entity. Then, Billy steals Grim's scythe, and uses it to open a portal to summon Yog-Sothoth. In consequence, Mandy calls for Hoss Delgado to battle Billy. It is revealed that the portal can only be sealed by throwing the book into it. As Billy eats the book, Mandy throws Billy himself into the portal, restoring everything to normal. Instants later, a portal opens up and Billy comes out and says they didn't want him there.

Mandy and her parents leave the city for a day, which makes Billy feel lonely. Then, Grim uses his supernatural powers to create a fake Mandy with pieces of dolls and toys for Billy to play with. However, the "new" Mandy is too aggressive with Billy, and he starts fearing her. The next day, the real Mandy returns home, and promptly destroys the new Mandy while in the see-saw.

In this musical episode, which pays homage to Little Shop of Horrors, Billy befriends a singing brain-eating meteor (voiced by Voltaire) that falls from the sky. With Billy's help, the creature grows bigger and eventually eats the brains of all people in Endsville (turning them into zombies with glowing green eyes). The last brain he eats is Mandy's, which results in the creature transforming into a brain-eating Mandy. The song featured is BRAINS!, composed by goth artist Voltaire specifically for this episode.

Billy, Mandy, and Grim eat moldy pizza leftovers, and after falling asleep, they have nightmares. Billy dreams of cute bunnies which turn into monsters; Grim dreams of an endless number of bossy Mandys; Mandy dreams of being pulled into a volcano and then commanding demons at the rhythm of music, in a scene that reminisces the Night on Bald Mountain segment of Fantasia. In the end, Mandy reveals that her dream was actually very pleasant, and she eats the last slice of the rotten pizza.

After watching Billy and Irwin play with their "Hokey Monsters" cards (parodying the Pokémon Trading Card Game), Grim makes the monsters come to life. Soon, all the other kids want their own cards to be real too, and the city is soon under attack by a multitude of Hokey Monsters. To put an end to the mayhem, Mandy draws her own card, Mandy's Monster, which defeats all the other monsters by turning them into toast.

Grim is lying sick in bed with "Encroaching Doom Syndrome". The Underworld doctors are not able to help Grim, and he becomes a human being. Back in Endsville, Grim seems attractive to women, but he ends up being punched by jealous boyfriends, especially Billy's dad Harold. Grim covers himself in the mucus that he produced when he was sick and becomes a skeleton again, and Billy tries it too.

Taking inspiration from his Pat the Baker video game, Billy decides to bake chocolate brownies. Billy uses "Evil Powder" from Grim's old trunk instead of salt, and the resultant brownies stink. Mandy tells Grim to get rid of the brownies, and he reluctantly does, but he also stores some of them in his skull. Soon, the stench of the brownies spreads through the world and starts resurrecting dead people, animals, and even food, as zombies.

Billy and Hoss Delgado, spectral exterminator, team up to destroy all the zombies that congregate outside the house, but the zombies reassemble into a bigger zombie. Delgado realizes that the zombie is after the brownies that Grim has in his skull, so Delgado and Grim battle furiously for them. The zombie eats the remaining brownies and falls apart.

On a hot day when Billy, Mandy, and Irwin are bored, Grim uses a crystal ball to show them the future. In the distant future, Mandy has turned herself into a giant worm-like creature to be immortal, and now rules the whole world. Mandy gives false information to a clone of Billy to capture the members of a resistance that try to defeat her. The episode parodies the science fiction novel God Emperor of Dune by Frank Herbert.

When Billy, Mandy, and Grim go fishing, Eris, the goddess of chaos, gets Billy to help her use the Apple of Discord to create chaos (after her father grounded her). Instead of using the apple, Billy becomes distracted with his own idiotic errands, leading Eris to go insane. Billy finally decides to start creating chaos, but Eris is already too altered that she runs away.

Billy accidentally sets off a powerful stink bomb in Mandy's house and, while the house is being disinfected and fumigated, Mandy's family goes to live with Billy's. Billy and Mandy have a dispute over how to split Billy's room, prompting Grim to intervene. Mandy takes over the entire room, and imprisons Billy inside a brick wall with his mouth gagged by a dark red handkerchief.

After excluding Mandy from their board game Who Killed Who? for being a girl, Billy and Irwin mistakenly throw their dice into the backyard of a haunted house. Grim warns them about the ghost of Mrs. Doolin, a lady that lived there. Mandy dares to go inside to retrieve the dice, and she befriends Mrs. Doolin, who is alive and well, and who says that all the stories told about her (that anything that went beyond her fence into her garden never came back) are inventions from Grim, whom she beat long time ago at a staring contest. Fearing for Mandy's life, Billy also ventures into the house, but Mrs. Doolin and Mandy scare him away by posing as ghosts. It appears that Mrs. Doolin is in fact a ghost, and when she meant "beating Grim", it meant that she "beaten death".

After Grim fails to pull a werewolf out of his hat, Irwin is bitten by said werewolf. Billy takes Irwin as his new pet dog, naming him Sprinkles, and enters him in the Endsville Dog Show to compete against Mandy's dog, Saliva. At the contest, Sprinkles is about to win, so Grim releases a "were-flea" whose bite causes the werewolf to revert to a naked Irwin. It appears that Irwin won the contest anyway.

When Billy, Mandy and Grim go to the beach, Grim falls in love with a goth woman named Malaria. Grim is having a good time with his girlfriend, but Mandy assures him that will change when he tells her that he is not human. In the following date, Grim demonstrates his supernatural powers while dancing and, as predicted, Malaria leaves in panic.

At school, Mandy rejects Irwin's invitation to go to the school dance with him. Billy introduces his foreign and mysterious, new friend, "Piff", and Mandy becomes desperate when she realizes that she has developed a crush on him. Mandy asks Grim to cut her heart out to stop being in love, but Grim has a better idea and gives Mandy a makeover. Piff gets a crush on Mandy, who takes the opportunity to brutally turn him down.

Billy is worried about failing an upcoming Math test, so Grim gives him a "bookworm", which will make him much smarter. Milkshakes, Billy's cat, eats the worm instead, and is forced to tutor Billy. Billy is still an idiot in the end.

Billy and Mandy are sent to "Winter Camp", where they meet Nergal's son, Nergal Jr. Just like his father, Junior tries making friends, although not in the best way possible. Junior attacks the campers, freezes them and, using his shape-shifting abilities, takes over their appearances. Billy decides to be Junior's friend, but he is scared away at the moment Junior shows him his true form.

After being accidentally hit by Billy, Grim lands in a can of white paint in a remote convent. Due to his appearance, still with the can in his head, Grim is mistaken for "Sister Big Mamma" by little nuns. Grim has a great time with the friendly nuns, until Billy and Mandy come looking for him. When the nuns realize the truth about Grim they get angry at him, but also help him go back home by sending him flying away with another punch.

When Billy and Irwin exclude Mandy and Grim from helping them build a go-kart to enter the Annual Endsville Go-Kart Competition, the latter two decide to build their own. Billy-Irwin, and Mandy-Grim compete against Mindy, Sperg, and a mystery racer (Pud'n). Mindy gets stuck in highway traffic, Billy-Irwin's car is destroyed, Sperg and Grim mutually prevent each other from winning, and Pud'n wins in his little red wagon.

After missing on a school trip, Grim takes Billy, Mandy and Irwin to the "Halls of Time" for a tour. There, Billy and Irwin mess the hourglasses that symbolize each person's lifespan. When they leave, they accidentally leave their own hourglasses, including Grim's, upside down, resulting in the group getting younger as time passes. Grim allows the kids to disappear by going before birth, but he cannot restore his own hourglass to its correct position and he disappears too.

When Billy crashes his bicycle, he obtains a free tricycle from a mysterious boy in a supernatural porta-potty. While Billy loves his tricycle, which he calls Trykie, he is also mocked because of it by Irwin, Pud'n, and Sperg. Trykie moves on its own and attacks the three of them. Mandy realizes the problem with Trykie, and Grim confirms that he is cursed. Billy realizes that Trykie is indeed evil as well, and he lets Mandy destroy it once and for all.

When Mindy mocks Mandy's dumb and coward dog, Saliva, Mandy decides to train her dog to be meaner. After Grim keeps mentioning his own dog, Cerberus, Mandy decides to use Grim's special whistle to call the gigantic, three-headed, fire-breathing hound. Cerberus marries Mindy's chihuahua, Little Delicious, and Saliva snaps against Mindy for a brief moment.

When Billy and Mandy are utterly bored, Grim takes them to Underworld's "Circus of Fear". The ringleader, Dr. Fear, notices Billy and Mandy, and tries to recruit them into the circus to attract customers, who would pay to see real, live humans. After they go back home, Dr. Fear captures the two kids, and Grim has to get them back. During the show, Mandy breaks free and in a strange twist of the story, she reveals that the beastmaster, Clortho, is actually Dr. Fear, who in turn is just an earthworm, leaving Billy confused.

As Billy walks into the woods to have a picnic, Yogi and a giant, feral version of Boo-Boo (from The Yogi Bear Show) come to steal his basket, and he escapes by hiding in a cave. Billy is taken to the mushroom lair of the dwarfs where King Beardbottom tells him the story on how the different races split the food-services industry, after the conference of Rivendell. The king sends Billy to infiltrate the elves' cookie factory to deactivate their force field, so the dwarves can assault the factory. After a fierce battle (censored out "for younger viewers", by a single clip of a pink koala continuously licking a eucalyptus leaf) and Billy's words, the elves and dwarves decide to work together and split the profits.

When Billy sees his father shaving, he decides having a beard is cool and buys "Hair Raiser Tonique", a hair-growing formula. Grim casts a spell on the tonic to make its effects appear faster, but Billy exaggerates the quantity and grows hair in all his body. Billy is mistaken for the Sasquatch, and a reward is offered for his capture. Hoss Delgado also receives the tonic and is captured and exhibited as the Sasquatch, while Mandy collects the reward.

After being bullied again by Sperg, Billy asks Grim to shrink him to enter Mandy's head to steal her "nerve". After Billy swallows the raw nerve, a polyp-like organism, Mandy becomes timid and scared of everything while Billy becomes tough and mean. While Billy goes to get revenge at Sperg, Mandy enters Billy's head to recover her nerve. Mandy recovers her tough and cynical attitude without her nerve, which is successfully retrieved from Billy and banished from Endsville.

When Billy forgets to do his history homework, Grim gives him a universal remote control to alter time and space so he can go back in time and finish his report. Billy and Mandy travel to the American Revolution, to prehistoric times, and even to the future, where they meet an aged Billy who is just finishing the report. After a struggle for the remote, Billy ends up again in the Prehistory and the remote breaks. Fast forward into the present, every person is dumb like he is and shares his characteristic big nose, including Mandy and Irwin.

After Billy wakes up from another nightmare involving clowns, he is more terrified than ever towards them, so Mandy and Grim try to cure him of this clown-a-phobia. Mandy asks Grim to bring to life a clown's head made on paper mache to entertain Billy, but the spell does not seem to work. They dress up as clowns in an attempt to look harmless. After consulting with his imaginary "Inner Frat Boy", Billy changes his feeling from being afraid to being angry at clowns, and attacks them with Grim's scythe. Billy is cured of his fear, but the paper mache clown attacks and eats them.