Cash-strapped Mrs. Huber figures out that Susan had something to do with Edie's house fire and tries to blackmail her. Meanwhile, Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect---the cable guy instead of gardener John. Also, Lynette balks when the twins' teacher insists the boys have ADD but tries to salvage the matter by seprating the boys. Lastly, Bree struggles with her rebellious son Andrew after Rex moves out.

Lynette locks horns with officious mom Maisy Gibbons at the twins' school who is trying to produce a "politically correct" play about "Little Red Riding Hood." Meanwhile, Susan continues to investigate the mystery of Zach's sudden disappearance. She soon finds out his father Paul put him in Seacrest, a mental institution. She and Julie then go to investigate.

Mama Solis comes closer to discovering Gabrielle's dirty little secret of her affair, and Bree comes undone when Rex suggests they hire a sex surrogate.

Susan and Edie decide to follow Mike and his houseguest Kendra on their night out together. Lynette becomes steadily more dependent on the twins' ADD medication. In the meantime Gabrielle becomes jealous of the "other" woman in John's life. And Bree's kids mutiny when they learn their dad has moved out. Tom is not happy when Lynette tries to take over his concept of new "Spotless Scrubs" to his clients.

In the aftermath of tragedy with Bree's son Andrew running over Carlos' mother Juanita Solis, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike's real reason for moving to the street. Lynette reaches the breaking point in her addiction to the twins' ADD medication as she tries other measures like acupuncture to release her stress. The mysterious Mr. Shaw gets down to business as he develops a relationship with Edie. Lastly, Gabrielle confesses her adulterous affair to a priest while Carlos' mother Juanita is in the hospital.

The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.