While Toby and C.J. are in California working on Sam's campaign, Josh drops Abbey's agenda in favor of his own, Jed deals with a military hostage situation, and Will runs his intern writing staff ragged.

Toby's old friend approaches him ready to blow the whistle on his employer's violations of environmental laws; staff pranks abound on Amy's first day at the office; Abbey charges Amy with the task of convincing the President to threaten a veto on a foreign aid bill containing an abortion gag rule provision; claiming that Abbey's ancestor was a pirate rather than a privateer, a prominent member threatens to mount a boycott of the D.A.R. dinner at which Zoey will be inducted until Will, C.J. and Amy devise a plan to defuse the situation; at the behest of Jean Paul, Zoey sends Charlie a "Dear John" email, but Charlie refuses to accept the brushoff and declares his love for Zoey; Donna is less than thrilled when Josh assigns her the job of shadowing a possible security risk at Zoey's D.A.R. induction; Will takes one for the team in putting an environmental and political face on the destruction and deaths which resulted from the melting of an Alaskan glacier.

The Bartet clan attempts to gather for a holiday dinner. Jed must deal with a hostage situation in Sudan, an assisted suicide in Oregon, his son-in-law's yearn to run for the House of Representatives, and his grandson's want to spend time with his grandpa. C.J. takes a stand on the assisted suicide because of her father's worsening condition.

Jed and the staff vet potential Supreme Court appointees; Toby and Andy don't see eye-to-eye on her fact-finding trip to the Middle East; Donna's parents are the unlikely inspiration for the resolution to the problems arising from the judicial confirmation process.

An airborne contamination alert locks down the West Wing, forcing staffers to stay put until the all-clear is sounded; Toby and Will face off over Will's working for the vice president; C.J. tells Donna some things she's rather not hear about Josh and her career prospects; Leo confronts Abbey about the dangers of her recent coping mechanisms; Jed, Debbie, and Charlie are poked, prodded, and sent to the decontamination showers; Kate is initially reluctant to give Josh any information on a personal or professional level as they sit out the alert together.

Margaret and Charlie prove to be invaluable allies as C.J. has a rough first day in her new position, made even more difficult by a Russian bearing radioactive gifts and a Defense Secretary's attempts to undermine her; Toby's less than stellar performance in the briefing room makes the search for a new press secretary a top priority, and Josh volunteers Donna to assist him in interviewing potential candidates; faced with a number of vulnerable seats in the upcoming election, Josh attempts to dissuade Matthew Santos from dropping out of another race for the House.

As acting chief of staff, Josh calls Leo in for backup when the news about Jed's health hits; the staff follows the progress of an asteroid headed for earth; Jed struggles with his relapse as C.J., Kate, and Toby handle the repercussions of his illness on the progress of the China summit; Josh is outraged when Will uses Jed's paralysis as a political opportunity for Russell; Donna resorts to extreme measures when Josh avoids her repeated attempts to sit down for a personal discussion; after receiving some wise advice from Leo about the future, Josh makes a decision about the man he'll support in the upcoming presidential election.

A new candidate for president, Senator Rafferty, has garnered much media attention with a ground-breaking speech about health care. But her words contain interesting echoes of President Bartlet's original health plan, which is known only to White House insiders, and reporter Greg Brock suspects that Rafferty is being secretly supported by the incumbent. Meanwhile, Toby is more than usually morose after the death of his brother. A bill to combat drought conditions in the western U.S. gives C.J. problems, particularly in dealing with lobbyist Clifford Calley. And Charlie tells Kate Harper that a man from his gym asked if she was dating anyone.

As everyone but Josh causes Santos to question his choice of Leo as his running mate, Bartlet's investigation into the dangerous press leak continues. Also C.J. gets interviewed by Babish and Donna approaches Josh for a job.

Lou and Santos run into trouble on the road when they try to pick up a family's vote; their child was shot by a Latino police officer. Also, CJ must manage a crisis between China and Kazakhstan.

After the near-nuclear disaster at the power plant the polls show surprising, or maybe not so surprising, results for both candidates. The Vinick camp gears up for backlash while the Santos camp hopes for cause to celebrate. Meanwhile Bartlet is still trying to keep the situation in Central Asia under control. Relationships in the Santos campaign, the Vinick campaign, and the West Wing all undergo changes and Vinick and Bartlet attempt to deal with different versions of the cold.

Former series regulars, including Marlee Matlin, Mary-Louise Parker, Tim Matheson, Anna Deavere Smith and Gary Cole, make guest appearances as Bartlet, Santos and their staff members attend a funeral for one of their own. Also, Josh cautions Santos about getting involved in the vote for Speaker of the House.

C.J. and Will both face uncertain futures as Bartlet and his staffers prepare to leave the White House to make way for the Santos administration.