No regresso após a captura de um criminoso de guerra, o helicóptero de Mac e Jack despenha-se numa área remota do Cazaquistão, ferindo o piloto e fazendo com que o prisioneiro fuja com a arma de Jack. Usando uma lâmina grande e uma garrafa de água, MacGyver tem de conseguir ajuda à medida que a condição do piloto se deteriora e antes que o criminoso de guerra os faça prisioneiros.

A primeira missão internacional de Bozer corre terrivelmente mal quando Mac e a equipa são acusados de um atentado bombista e a Phoenix Foundation é forçada a repudiá-los. Usando uma régua e óleo de coco para disfarçar, a equipa tem de evitar as autoridades e limpar o seu nome sem qualquer apoio de casa.

Using a cassette player and a plastic bucket, Mac and the team attempt to extinguish a massive oil wellhead fire in a Nigerian village, set by a rebel group, which is trying to topple its government by destroying their most valuable resource.

When 32 college students are stranded on a research ship in the Arctic Ocean with no heat and erupting fires, Mac develops an emotional connection to the group leader, via video chat, as he relays how to stay alive as they await a rescue ship. Also, Jack kidnaps Elwood to find out what scam he’s up to next, and Bozer’s feelings toward Leanna grow stronger.

When Oversight’s attempt to capture a drug cartel’s leader goes bad, MacGyver and Jack rush to Mexico to pull their boss out while racing through the heart of the country during Dia de Muertos celebrations. Also, Bozer and Riley use Halloween as a distraction to gather intel on a man accused of treason.

Matty sends MacGyver and team to Ghana to recover a hard drive from an e-waste landfill that is run by a powerful and violent man. But when Matty refuses to reveal what’s on the drive, other than a mysterious file called “Dragonfly,” the team speculates about what could be so important to her.

Matty reveals a shocking secret to the team: she has a husband who’s been undercover in a criminal organization called S-Company for eight years. When his status as a CIA agent comes out, Matty needs MacGyver to find and extract her husband before it’s too late.

As MacGyver works quickly to rescue survivors from a collapsed building in Germany, he discovers a new safety threat – a 1,000-pound undetonated bomb from World War II hidden beneath the rubble.

During COVID-19’s first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor’s house. Also, Russ’ romantic fling takes on a longer and more complicated turn when they quarantine together.

The secret experimental cancer treatment Mac’s developing with a friend is discovered when culprits ransack their lab, kidnap Mac’s partner and plan to use the research to create a powerful new nerve agent.

While Mac and the team delve into the world of Italian car culture in order to track down a crime boss-in-hiding, Mac must lean on Desi when he discovers that he losing the ability to control his hands. Also, Mac and Desi move in together and Riley reveals the truth about her secret team of hackers to Russ.