Laurel continues to investigate the death of esteemed Dr. Daudier, while bugs infect more citizens of Washington, D.C. Rochelle Daudier, the deceased doctor’s daughter and Gustav Triplette, an eccentric genius, both encounter the bugs separately and begin to question exactly what is happening.

When a bizarre and deadly incident takes place on live television, Agent Onofrio's investigation into it causes Laurel, Gustav and Rochelle to dig deeper into the bug mystery. Luke attempts to cover up his affair with his Chief of Staff, Scarlett, before his opponent for the minority whip position, Senator Ella Poundstone, can make it public.

When Laurel is infected by the bugs, Gustav and Rochelle work quickly to figure out if there is any way to save her. When the Centers for Disease Control has its funding temporarily cut, Luke attempts to reach a compromise to have the money reinstated, but Red’s political machinations undermine him at every turn.