April finds herself in a dangerous situation and Natalie gets an update on Will. Dr. Rhodes gears up for a gala honoring his hybrid O.R. and tries to convince Dr. Bekker to join him.

Halstead takes heat for making an unauthorized move to treat his pregnant patient. Choi becomes personally invested when treating a homeless veteran. Rhodes and Bekker deal with a patient who desperately needs a liver transplant.

Connor, who is in hot water with the hospital's Oversight Committee, handles a gunshot victim with unexpected ties to Halstead. Maggie feels guilty about the return of a former patient. Charles has an awkward first date.

Halstead treats a woman on the verge of freezing to death. Dr. Charles' ex-wife receives some concerning news. Choi handles a lymphoma patient with viral meningitis and a complicated family. Manning makes a house call.

When a car unexpectedly smashes through the ambulance bay doors, Dr. Choi makes some difficult decisions in an effort to save a worker trapped beneath the wreckage and April, who's also in danger.

Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself. Dr. Rhodes throws some serious accusations at Dr. Bekker. Dr. Halstead has suspicions about Natalie’s new boyfriend and Dr. Choi tends to Bernie.

Dr. Charles and Caroline set some major plans. Ava fights to keep her relationship with Connor. Agent Lee informs Will of news that may put his life in danger.

Will and Natalie battle for their lives after a car accident. An investigation is launched following the suspicious death of Cornelius Rhodes. Maggie receives life-changing news. Dr. Charles cuts his honeymoon short to tend to a patient.

A power outage at Med puts multiple patients at risk and tests the skills of the staff and their enthusiastic med students; Natalie returns following her traumatic brain injury; Ethan and April wonder if a family is in their future.

Dr. Choi and Dr. Charles have difficult decisions to make as a dying man tries to preserve his life with a controversial scientific method. Dr. Marcel and April clash over how to handle a mysterious patient. Will questions Natalie’s capabilities.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.