In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.

While searching for Jennifer Goines in post-WWI France, Cole and Jones encounter a dangerous group of time- travelers - the Guardians.

Bonds of trust are tested when Ramse returns to the facility with an old enemy held captive. How far will Cole and Jones go for the answers they need?

Ramse and Cole splinter to 2007 expecting either a trap - or a final chance to kill The Witness. But when Cole discovers a heartbreaking truth, he’ll discover that the mission was both.

The final battle with the Witness begins.

The final conflict with the Army of the 12 Monkeys begins when the Witness returns to Project Splinter.

Cassie travels back in time to confront a younger Olivia; Cole helps Jennifer find the meaning behind her final Primary vision.