In the white-hot sun of the New Mexico desert, scientist Vera Buckley watches in fascination as a mysterious object plummets to Earth and explodes in a blinding flash, sending out a shock wave that briefly stops Vera’s heart and panics her techie coworker Alan Harris.

Drawn together by destiny, Vera, Erin, Joshua, Raul and Peter convene together where they meet the mysterious Rose. Rose reveals that they are angels and their mission is to find and stop the Four Horsemen of the Apocalypse from bringing about the Rapture. Meanwhile, The Man’s real identity is revealed and he continues to tempt Vera with clues about her missing son.

The Messengers struggle to stay together and on mission when an unforeseen setback causes them to question whether being an Angel is causing them more harm than good. In the process of pursuing their own desires, the Messengers discover that destiny has a strange way of bringing them back together.

The Messengers' powers are tested as they attempt to rescue someone from government lockup. Meanwhile, Joshua has a vision foreshadowing the arrival of a deceptive new adversary.

A battle between the Messengers and the Four Horsemen takes place as the Horsemen try to break the fifth seal in the series finale.