Seth escapes the motel and leads the Fullers' RV to the border. Meanwhile, Richie deals with an irrational fear; and Jacob is determined to get his children safely across the border.

Seth and Richie face the labyrinth in the temple; Jacob and Kate confront Scott's transformation.

Kate hunts down Scott in Bethel before he can exact revenge. In Houston, Richie and Santanico find themselves deep in the flesh trade, while Seth tries to get back in Uncle Eddie’s good graces.

Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.

Freddie joins forces with an old enemy in order to destroy a demon who's enslaving culebras. Seth and Richie track down an ancient hunter.

As Kate nears death, the team races to defeat Amaru and seal the gate to Xilbalba.