After a slew of brutal slayings, District 21, led by Sergeant Hank Voight go after a Columbian drug cartel cleaning house in Chicago. They discover D’Anthony who proves to be an asset in the investigation. At District, complicated histories and unit rivalries surface which could end up costing them one of their own. Meanwhile, Rookie Kyle Ruzek is pulled from the police academy by Olinski to join the team.

Antonio’s son was kidnapped and he has a feeling the Columbian drug gang is to blame. Pulpo, the Columbian gang leader, is being held in jail and suggests his release may trigger the release of Diego. During the investigation, Halstead learns some new information about Lindsay. Voight offers Antonio a new approach to get information on Diego’s whereabouts.

Antonio heads undercover with a dangerous robbery crew after a narcotics officer goes missing.

Lindsay goes undercover to catch a rogue cop who targets women at casinos. Platt risks her life in a negotiation crisis.

When a young Latina woman is brutally murdered, Intelligence suspects she may have been working as a drug mule. With Antonio leading the case, the team's investigation takes them into the grim world of meat processing, and the discovery that there may be a different motive behind her death.

Intelligence investigates a string of bombings targeting members of the media. Racing against a ticking clock, the team enlists Firehouse 51 to help examine the devices and prevent the next attack.

The crossover continues on Chicago Fire S06E013 Hiding Not Seeking (II).