Sarah is deeply wounded and struggling to stay alive on the Island. Driven deep into its forest by Neolutionists and worse, she strives to make it far enough to rescue Cosima. Meanwhile, a recovering Cosima reunites with Delphine, but there's way more going on on this Island than Cosima imagined and Delphine can't give her all the answers she needs. What is clear is that Rachel is now firmly in charge as the right-hand of the 170-year-old founder of Neolution, P. T. Westmorland. Back home, Neolution puts the screws to Alison and Donnie in their hunt for Helena. The sestras couldn't be further apart when they need most to be together.

Following up on intel from a mysterious source, Mrs. S heads on the road with Sarah to investigate a lead on a Neolution defector. Meanwhile, an unexpected reunion takes place on the island, while Cosima's research leads her to a discovery more terrible than she could have ever imagined. As more pieces slide into place, the puzzle only seems to become more complicated.

While Sarah and Kira spend some well-needed bonding time at home, secrets are unlocked about Kira’s special gifts that are surprisingly linked to the island’s creature. Meanwhile, Cosima joins Delphine at the mansion for a twisted family dinner, causing a dangerous showdown with the Neolution patriarch.

As P. T. Westmorland demands a more aggressive action on Kira, and Sarah fights to save her daughter, Rachel discovers a dark secret that makes her question her place within Neolution. Meanwhile, Cosima has returned with a vital clue to Westmorland's true identity.