Kovac anxiously awaits the verdict between himself and Curtis Ames but fears the worst. Meanwhile, Neela disobeys her chief's orders and also questions her feelings for Gates, and Weaver unwittingly steals the spotlight from Morris in his big television debut.

Kovac and Gates deal with a hopeless father whose son succumbs to heart failure; Pratt tries to resolve the tension between him and his brother; an Armenian man tries to be a good samaritan but ends up crashing near the ER; Abby sneaks in baby Joe when she worries his sickness may be worse than it seems; Also, Sam injures the instructor of a self-defense seminar.

In 12 hours, the ER will shut down. As Kovac is under pressure to take care of the patients before the final hours, he makes a pivotal decision about his future. Meanwhile, Sam befriends a photojournalist who returns only this time she's terminally ill; Pratt is concerned when his brother ends up in the ER drunk; Morris confronts Gates when he ignores his orders and angrily sends him home while Gates tries to defend his actions.

Dr. Kevin Moretti, an ICU specialist bent on change, joins the ER team. Change comes elsewhere as Luka and Abby adjust to being husband and wife, Pratt tries to be a new man to his lady friend, Morris and Hope take things to the next level, and Ray goes missing. Later on, Luka gets a troubling phone call.

Moretti begins to make his presence felt, as he implements changes in the way patients are seen. The ER staff differ on how procedure when a patient comes in with a bullet in him needed as evidence. Neela finds herself the object of more attention that she wants, or needs. Abby had passport woes, and struggles with the changes being made. Pratt and Morris find themselves forced to defend their actions, Hope prepares for a new mission, and Gates finds himself labeled the reject in his new assignment.

Two wounded police auxiliary officers present challenges in the ER. Neela settles in with Abby as she recovers, while Pratt and Bettina consider their relationship. Gates tries to get a patient on a drug trial, with Dubenko's help. And Morris is in a funk that not even a pretty woman can help.

When Baby Joe is injured by a fall at the playground and rushed to the hospital, Abby is unable to reach Luka to tell him.

After being passed over for Chief of the ER, Pratt is looking for a hospital that will appreciate his talents. A former employee of the ER brings her sick son in for tests. Neela's cousin is in town for a visit, and Morris and Harold compete for her affections.

Neela's short visit in Ortho turns into a game of hockey. Bettina wants to take her relationship with Pratt to the next level, but Pratt is not keen on the idea. Gates and Sam disagree over a patient. Julia provides some spiritual guidance in order to ease a prison doctor's bad conscience.

Neela, worn out after being on shift for over 24 hours, has to make a quick decision regarding an accident victim's torn aorta. Sarah's grandparents are in town, and Hank is rushed to the ER after collapsing during an outing. Gates tries to convey to Sam that his feelings for her are serious.

Neela's aortic rupture patient is in need of yet another follow up surgery, and they are starting to take a toll on her. Morris talks with a shrink about his experience with the jewelery thieves. Abby needs to make a tough decision when a new opportunity is presented to her.

Abby awakens after the ambulance explosion and rushes to check on Pratt; Sam and Gates rush to the scene; Morris and Neela struggle to keep up with Pratt's injuries.