A woman who wrote a cheering letter to Ironside when he was recovering from being shot, dies in an apparent suicide. Convinced that it was murder Ironside investigates, and uncovers the sad truth. (NB - As part of the incidental music, this episode heavily features the original song From The Day You're Born, which was reused later in the season, in episode Something For Nothing, where it was sung by guest star James Farentino).

A local businessman sets up an organized vigilante force to try to clean up San Francisco. When a key member is murdered, it becomes clear that the "Second Force" has got severely out of hand.

When Ed and two colleagues arrest a violent man they don't take his threats seriously, but when the other two officers are murdered, Ed is convinced that he knows who the killer is. Suspended from duty he sets himself up as the next victim, determined to prove that his suspicions are correct.

A psychiatrist friend of Ironside's is murdered, and the only clues are his collection of artworks. Is one of the artists the murderer? And if so, which one?

Ed is charged with police brutality following a raid on a hippie drug den. As always, of course, things are far from being as they seem, and the trail leads to a group of apparently model students at a local private school.

A notorious jewel thief named Justin arrives in town at the same time as a shipment of famous jewels arrives for display in a local museum. Ironside must keep the thief guessing about the method of shipment so that the jewels will remain safe; but he is up against a mastermind and there is still an inside man who has to be unmasked.

A old woman is murdered, and the only witness appears to be a large, grumpy Alsatian. The Chief enlists his help in a search for the murderer, and uncovers a story of con-jobs and blackmail suggesting that the old woman was far from being just a helpless victim

A Torah is stolen from a local Synagogue, presided over by an old friend of the Chief's. Ironside personally takes on the case, determined to find out if the theft was an act of vandalism, as the evidence would seem to point out, or if it is really the work of thieves looking for some quick money.