A young teenager has been rejecting her mutant powers ever since she discovered them. But when giant robots track her down, it's up to the X-Men to save her.

Breaking into the Mutant Control Agency's headquarters to destroy the registration files on mutants, the X-Men lose two of their members against the Sentinels, but eventually gain another.

Gambit, Storm, and Jubilee become slave labor on the island resort of Genosha, along with other mutants, forced to help build the new power source for a Sentinel factory. They're given aide in escaping by a mysterious mercenary named Cable.

At a Mutant/Human Relations Summit, Henry Peter Gyrich attacks.