A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).