Iria visits her home province of Batabitajira, only to be attacked by a Zeiram-produced clone. Yet Iria senses that somehow, this encounter with the Zeiramoid being was no accident, and somehow, it was waiting for her...

Meanwhile, citizens of the Capital City of Myce are disappearing at an alarming rate. Worse still, it seems that more and more hideous creatures are being unleashed upon the city. And at the epicenter of all the activity stands Zeiram, who can not only produce genetically cloned beings to do his bidding, but also call more Zeirams from beyond the Mycean planetary system...