Frank and Bob Bletcher hike across a remote snow-covered mountaintop in the spectacular North Cascades region of Washington State. Their trip is cut short when Frank receives an important page from the FBI.

Attorney Al Pepper walks through a supermarket parking lot carrying a bag of groceries. A teenager, Sam, addresses Pepper and extends an open palm. Frank exits the supermarket and sees the two men. Suddenly, a bolt of light emanates from Sam's palm, knocking Pepper to the ground. Frank runs towards the scene, passing through panicking shoppers. When he arrives at Pepper's side, he discovers a handgun lying at Sam's feet.

Frank aids in the search for a man who is supposedly carrying a highly contagious virus and discovers the secret behind the Human Genome Project.

Novelist Jose Chung authors a short story critical of a millennial self-help movement... and performs some profiling of his own when a college professor is found murdered.

Serial murders in the guise of assisted suicides stymie Frank, whose primary suspect is a charismatic hospice nurse. Frank and Lara investigate to determine if it is murder.

As the schism between the two warring Millennium Group factions deepens, Frank discovers the existence of yet another player in the power struggle.

A mysterious Asian woman is linked to several strange deaths aboard a ship.

Frank senses that Bletcher's killer is responsible for the disappearance of a teenaged boy.