Ed Davenport learns that a sandwich he requested to be tested by a lab contains arsenic and blames his wife Myrna. When he confronts her about his suspicions she denies it. He leaves for a business trip and falls ill. Dr. Renault is called to treat him at a motel where Ed Davenport later dies. Before he dies he claims his wife poisoned some candy. After locking the motel room the doctor calls the police. The police arrive to find the corpse missing. The police test the candy and indeed find arsenic. Subsequently Ed Davenport's body is found in a shallow grave. Myrna Davenport is accused of the murder.

Dr. David Craig discovers that tapes of conversations with his psychiatric patients are missing and being used for blackmail purposes. When the suspected thief and blackmailer, Mark Douglas, turns up murdered, the good doctor is charged with the crime.

Ruth Prescott wants to divorce Walter Prescott so that she can be with her true love, Jimmy MacLaine. After a brush with death, Ruth becomes convinced that Walter is trying to kill her rather than give her the divorce. Walter then turns up dead and the police are convinced that Ruth shot him but Perry, as usual, doesn't think so. A lame canary and unusual bruises on the victim hold the keys to the puzzle.

Bruce Chapman returns home early from a business trip to find that his wife, Marie, wants a divorce. Chapman is shocked at this turn of events because just before he left on his trip he thought he had found the strangled body of Marie in his office. But if Marie is still alive, who was the dead woman in the office?

Allen Sheridan has more enemies than you can shake a stick at. even though he's due to inherit the healthy sum of $162,000.00. When Allen turns up dead his killer could be anyone but his cousin Sarette becomes the prime suspect.

Lester Martin's life takes a horrible turn for the worse when a man breaks into his apartment, forces him at gun-point to drink half a bottle of Scotch, and then drives him into the country. Lester's circumstances then go from awful to good grief when he's charged with the murder of his step-father who was trying to takeover the family boat company.

Inventor Walter Randall wants a divorce from his cold-blooded wife Laura in order to be with Phyllis Hudson. Laura decides to get back at Walter by blackmailing one of his assistants into building a bomb that will destroy Walter's underwater sounding invention. While checking on the bomb in the warehouse, Laura is discovered by Phyllis and takes advantage of the situation by knocking her rival out. Phyllis manages to survive the explosion but she is later charged with Laura's murder.

A mixed up mess awaits Perry as he struggles to put all the pieces together. Blackmail, murder, a boyfriend who spent the night, all add up to one great case.

Aspiring screenwriter Herbert Simms submits his first teleplay to producer Charlie Corby who tries to use the manuscript as his own. Corby's scheme comes a cropper when he gets fatally whacked over the head with a whiskey bottle after a party. Herbert happens to be in the wrong place at the wrong time and is seen running from the scene of the crime. Guess who gets arrested for murder?

Mason goes to the dogs when his defense of a murder suspect hinges on a surprise witness.

Janice Barton is found guilty of the murder of her wealthy relative and sentenced to death. Can Perry find the evidence to clear her of the crime before the pellets in the gas chamber fall?

Wealthy but dying Bebe Brent gives the bulk of her estate to her loyal nurse. Needless to say, this act angers the remainder of the Brent clan and leads to a murder.