Will resumes his therapy with Dr. Lecter. The FBI investigates the murder of a woman whose body was found sewn inside a dead horse.

Margot Verger seeks out Will as she tries to understand Hannibal. The FBI searches for an animalistic killer who tears his victims' bodies apart.

Will's readiness to go to dark places strengthens his bond with Hannibal.

Will and Margot hide her pregnancy from Mason. After Freddie's gruesome murder, Alana's doubts about Will and Hannibal grow stronger.

Bedelia returns and accepts immunity to testify against Hannibal. Mason Verger plots revenge after learning of Hannibal's manipulations.

After surviving a disfiguring gunshot, Dr. Fredrick Chilton is now focused on rallying support to capture Hannibal, using Will as bait. Jack is distracted by Bella's failing health, but he implores Will to abandon the risky idea of finding Hannibal. Meanwhile, Alana Bloom entertains a different approach, potentially partnering with Mason Verger to utilize his vast resources.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. With Pazzi murdered, Mason and his cohorts consider a different course of action. However, Chiyoh has arrived in Florence with her own agenda.

Captured in Italy by police on Mason Verger's payroll, Will Graham and Hannibal Lecter are delivered to Muskrat Farm to await Mason's revenge. Alana, distressed that Will has been endangered along with Hannibal, plots a rescue. And Hannibal, once again in contact with his old patient Margot, finds it irresistible to remind her that Mason will never make good on his promises. Meanwhile, Jack informs Chiyo of Hannibal's location.

In a desperate bid to slay Francis Dolarhyde, Will Graham engineers a cunning ploy utilizing Hannibal Lecter. Upon learning of his plan, Bedelia Du Maurier voices concerns that Will's actions may not only put his life in peril, but the lives of those around him. As the end draws near, Will remains unflinching in his game with Hannibal-even when it means coming face-to-face with his own darkest fears?