When a young man in a cult claims to be hearing the word of God, Pierce must determine if it’s actually the word of God or a life-threatening neurological condition. Pierce and Moretti must also figure out if his murder is linked to his drug past or his new life with an organization that may be scamming people out of their life savings. Roger Bart guest-stars as Ethan Kendrick, a high-powered IRS agent looking into the finances of the organization. Meanwhile, the university gives Pierce an award for his research.

Pierce must take a deep look into his own life when he is brought into a case involving a schizophrenic. Meanwhile, Moretti stops at nothing to impress her new boss at the FBI. Guest star Tom Sizemore plays a top-level Irish mobster, while guest star Edward Furlong plays a would-be tough guy who may have played a crucial role in the crime.

Pierce and Morretti plunge into virtual reality to solve the murder of Kurt Simpson, a man who spent most of his time in a massive multiplayer online game called Caleidoscope. After creating an avatar of himself to investigate the crime, Pierce struggles more than ever to distinguish between reality and fantasy.

Lewicki's brother shows up unannounced; Kenny is named the key suspect in a homicide case; Lewicki is approached with an offer that makes him question Pierce's loyalty.

Pierce receives a tip that the CIA might be assassinating U.S. citizens; one of Pierce's close friends is murdered; Moretti tries to overcome her trust issues.

Pierce's mental stability is questioned and his job threatened when he is accused of stalking his ex-girlfriend, Caroline Newsome. As the situation escalates, Moretti works to find the real stalker with help from a visiting inspector from Canada.

After a young victim with a developmental disorder is taken hostage in a bank robbery, Moretti brings in Pierce to interview the boy. When they finally track down the culprits, they discover the case is about much more than money. Meanwhile, Pierce’s estranged father James pays him a visit.

Moretti calls on Pierce to examine Elena Douglas, a woman who has confessed to murder and claims to be possessed by the Devil. Meanwhile, Donnie and Moretti’s wedding plans hit a bump in the road.