Leo finds out that he will be a student at the bionic academy, not a mentor like Adam, Bree and Chase. Chase engages in a battle against a former nemesis and Adam mentors a younger student.

Donald leaves the Lab Rats in charge of the bionic academy while he celebrates his anniversary with Tasha. Leo invites Janelle to the island, but gets distracted by his nemesis, Spin. Spin challenges Leo to a bionic battle. Meanwhile, Adam tells Bob to do all the things he can't do when Donald is around. Bob goes ahead and steals Donald's plane, but he then hits a button that deactivates the auto-pilot. Sebastian and the Lab Rats work together to save Bob. Back at the bionic battle, Leo tries to impress Janelle by battling with Spin. Spin gets the first attack and knocks Leo over. Leo then fights back and hits Spin in the leg. Janelle rushes over to Spin, who is crying, and helps him up. Janelle gets upset at Leo and takes Spin to get a smoothie. It is then revealed that Spin faked the injury so Janelle would spend time with him. Leo tries to prove that Spin is faking it by taking his crutches. Janelle then yells at Leo and carries Spin away. Leo tries again by filming Spin admitting faking the injury, but Spin then smashes Leo's tablet. Janelle walks in and yells at Leo and Spin. Leo and Spin then become her servants and they must give her the vacation that she deserves. Later, Adam uses Donald's jet wing to fly up to the jet and save Bob. When Adam tries re-activating the auto-pilot, the plane begins to fall. Adam helps Bob conquer his fear of heights by jumping out of the jet. Bob takes Adam's parachute and Adam jumps out to try to get it from Bob. At Donald's house, just as Donald finishes setting up the table, Adam and Bob fall through the ceiling. Donald is disappointed with the Lab Rats. Adam confesses and tells him that he wasn't a good mentor. Bob tells Donald that Adam was a good mentor by boosting his confidence. Donald then tells him that his plane was a smart plane that even without the auto-pilot the plane would land itself automatically.

When Leo is chosen for a mission over Spin, Spin recruits Bob to join him on an unauthorized mission to prove themselves. They both end up stuck in quicksand and call Leo to save them. After Leo rescues them, Donald decides to move Leo up a color. Meanwhile, Principal Perry returns saying that she wants a job as head of security at the academy. After countless attempts, Donald agrees, leaving Leo in a particular despair. Meanwhile, Sebastian tries to help Chase get revenge on Adam with a virtual reality machine. After that, Chase tells him about his creator and how they took him out. Later, Sebastian injures Donald with the machine used to prank Adam. When the Lab Rats take Donald to the medic, Sebastian turns evil and says that if they took away his father, then he is going to take away theirs.

Sebastian has secretly formed an evil rebellion to get revenge on the Lab Rats for destroying his father. Meanwhile, Leo is trapped with the other bionic people who also want revenge, but Leo manages to convince Spin and Bob to help him, and, in the end, Sebastian is defeated, his rebellion is brought down, and he and his comrades are taken to a facility. Meanwhile, Donald successfully convinces the others that he has the best interest for them at heart while Adam still blames Chase for everything that happened after the rebellion is over.

Sebastian has secretly formed an evil rebellion to get revenge on the Lab Rats for destroying his father. Meanwhile, Leo is trapped with the other bionic people who also want revenge, but Leo manages to convince Spin and Bob to help him, and, in the end, Sebastian is defeated, his rebellion is brought down, and he and his comrades are taken to a facility. Meanwhile, Donald successfully convinces the others that he has the best interest for them at heart while Adam still blames Chase for everything that happened after the rebellion is over.

After sneaking some students off the island and to the mainland, the Lab Rats accidentally leave Spin and Bob behind and must retrieve them before Donald finds out. Meanwhile, Donald tries on Chase's mission suit and he and Leo scramble to get it off before Chase gets home.

The Lab Rats are on a mission to save people from a wildfire; when the people start to chant Adam, Bree, and Chase's names, Leo gets jealous and wants to become known. Douglas gets put in charge to develop a new technology for the academy, but can only come up with things that can hurt the students.

When Leo is injured during a mission, Tasha rushes to the academy to take care of him. After finding out what happens on missions, she bans Leo from joining any more missions, but he disobeys her and goes on a mission with the rest of the team. When Tasha finds out, she kicks Leo off the team and tells him that he is moving back to Mission Creek.

Donald's top scientist, Dr. Ryan, arrives to test Chase's invention. The two of them dislike each other and don't get along. When Donald puts Dr. Ryan in charge of the space elevator, Chase immediately gets jealous. Donald then makes Chase Dr. Ryan's assistant. Dr. Ryan puts Chase in charge of screwing in the lug nuts, but Chase refuses, and Dr. Ryan builds the space elevator without Chase. The day of the launch, Chase performs a bionic scan of the elevator and finds a major braking flaw on the elevator.

Douglas creates a device that makes any bionic human as smart as Chase. After Douglas tests it on Bob, Bob starts spending time with Chase. This leaves Adam in envy. Meanwhile, Perry made the island officially her own, which makes Bree and Leo angry at her.

Leo just finishes his movie marathon while everyone else is frustrated because they have nothing to do on Halloween. Bob intentionally stays behind while the other students are away with Davenport to a museum. Perry says she's going to another island across from theirs, but Douglas says no because it's deserted and has been uninhabited for years. When Douglas leaves, the group decides to go anyway.

Tasha arrives on the Bionic Island informing everyone that she has tickets to a big football game of the Pioneers (mascot of a college that she went to) vs Vikings (mascot of a college that Perry went to) and Perry arrives stating that she has been trying to score tickets for weeks but it was sold out. When she asks Tasha if she has any tickets, Tasha lies saying that she hasn't. When they are about to enter the game, Perry eventually finds out the truth, she becomes furious and destroys the tickets which causes Leo, Donald, and Tasha to try to get new tickets competing against her in The Ultimate Tailgate Challenge, hosted by NFL former linebacker Willie McGinest. Meanwhile, Bree attempts to achieve her college experience by fitting in with a couple of college students (who are football fans) and attempting to use her bionics to impress them.

Donald and Douglas reveal that they have built an upgrade for all the students bionics, except for Leo's. But the upgrade doesn't work on Adam, Bree, and Chase because their systems are older. Adam, Bree, and Chase are therefore left at their level, while all the students are much more powerful. Meanwhile, Daniel is brought to the Academy because he had been using his bionics in the outside world. Douglas decides to enroll Daniel at the Academy, and he makes Leo his mentor. Leo steadily tries to teach Daniel, but Daniel proves to be unteachable, so Leo gives him the upgrade as well. The students steadily start to vanish, including Daniel. Giselle Vickers, Douglas' old girlfriend, is revealed to have captured them. Daniel sends a video message to the Island, requesting help.

Giselle reveals she dug up Marcus from Douglas' old lair and rebuilt him, piece-by-piece. Marcus wants revenge on Douglas for leaving him to die. Everyone rushes Giselle and Marcus, but Marcus knocks everyone unconscious. Donald and Douglas are tied together in chairs, while Adam, Bree, Chase, and Leo are put in the chamber with the students, while Daniel is pulled out.