The first season of the television comedy series Mike & Molly aired between September 20, 2010 and May 16, 2011, on CBS in the United States. The season was produced by Chuck Lorre Productions and Warner Bros. Television, with series creator Mark Roberts serving as executive producer along with Chuck Lorre, James Burrows and Don Foster.

The series focuses on the title characters Mike Biggs and Molly Flynn, a couple who meet at an Overeaters Anonymous meeting in Chicago, Illinois. After Molly, a primary-school teacher, invites police officer Mike to give a talk to her class, they begin dating. Molly lives at home with her mother Joyce, and sister Victoria. Joyce is in an on-off relationship with widower Vince Moranto, who is often seen at the house. Mike lives alone in an apartment but is regularly kept company by his best friend and partner in the police force Carl McMillan. Other prominent characters in the series include Carl's grandmother Rosetta; Mike's mother Peggy and cafe worker Samuel. Season one of Mike & Molly consisted of 24 episodes and aired Mondays in the United States at 9.30 p.m. until April 11, 2011, with the final three episodes airing at 9.00 p.m.