A female jogger is found dead in Schuylkill River and Megan teams up with medical investigator Peter Dunlop to investigate her whereabouts before her murder. Meanwhile, Megan spends the day trying to solve a personal problem concerning her daughter's birthday.

When a young, interracial couple is found shot and killed inside their car in Fairmont Park, Dr. Megan Hunt promises the grieving parents that their daughter’s killer will be found. Detectives Bud Morris and Samantha Baker are ready to chalk the case up to a murder-suicide, but Megan and her team find evidence on the bodies that sends the case in an entirely different and shocking direction. Meanwhile, Peter advises Megan not to push too hard when it comes to reconnecting with her daughter, Lacey.

Curtis questions Ethan's interest in the investigation of the mysterious death of a beautiful twin; Megan runs into resistance while investigating the death of a patient at the hospital where she used to work.

Megan and the team investigate when a Philadelphia homicide detective is killed in a hit-and-run; Megan turns to her mother (Joanna Cassidy) for help.

Many suspects emerge after a rich tycoon's new, young wife is shot during a deer hunt; Kate and Megan's relationship takes a turn for the worse.

When two young girls are in a tragic car accident, one is left in critical condition and the other is found dead at the scene. As Megan and her team investigate the case, however, they realize there has been an awful mistake. Not only was the wrong girl pronounced dead, but the car accident may not have been the actual cause of death.