Many returns to Casa Martini: Guido has returned to his experience in Africa, Lele returns with the twins. Absent instead Cettina and her family: the former housekeeper Martini has apparently disappeared in a shipwreck.

A nasty surprise awaits Guido and Maria: in fact, the two discover that the tenant of their apartment does not want to return the keys. During a chat, Nonno Libero reveals to Lele that he feels the weight of her old age.

Grandpa Libero left, it's up to Lele to look after the whole family. Elena and Bobò are anxious about their first day of school. Annuccia continues to behave rather arrogantly towards her younger brothers.

Maria is entrusted with the case of a little girl hospitalized for some stomach pains probably due to the absence of her grandfather, who left on a long journey. Maria discovers that the truth is much more painful.

Fanny and Maria become friends, but Maria is jealous because she fears that Fanny will flirt with Guido. She does not imagine that the young colleague is interested in another member of her family: her father.

Maria's pregnancy proceeds and cravings also arrive. Meanwhile, a child neuropsychiatry department will also be opened at the clinic, which is precisely the specialization of the young doctor.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile Guido is refractory to the idea of starting a relationship with his newly found mother. Fanny discovers toxic waste dumped in a river.

Guido and Ave have a tough confrontation and the latter makes the fact that she hasn't been there in times of need increasingly weigh on her. Giulio wins the trio in the lottery and an unexpected snow in Poggiofiorito decorates Christmas day.

Maria prepares an exclusive evening for her and Guido, who is forced to stand her up. She feels a bit excluded from Guido's life since she is expecting a baby, and is convinced that he no longer likes him since he has a big bump.

As the last months of pregnancy approach for Maria, Lele feels that becoming a grandfather will be a new adventure, completely different from being a father. All the more reason because Mary's waters break early!

Nonno Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she is really in love with her.

Giulio convinces Nonno Libero to participate in a new program, Cambio Nonno. Libero accepts and finds himself with a new family, moreover, from Lazio. As a result, that family's grandfather moves in with the Martinis.

The twins notice the silhouette of a woman behind the window of the Torello house and believe that it is the ghost of Cettina. Nonna Enrica, in this regard, organizes a séance to evoke her together with her friends.

A friend of Annuccia surprises Fanny and Lele. Annuccia, after finding out from her friend, doesn't accept her father's new girlfriend, unlike the family who are still a bit confused.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Fanny decides to introduce Lele to her family. She has received permission from the Martinis to move into their house, because the maid Melina is unable to look after the child alone.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

The Martini family is summoned by the police because an American woman asks about them. The Martinis discover that the woman is actually Cettina, even if she seems to remember nothing of her past.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

The Martini family organizes a surprise birthday for Lele, desperate because he thinks of the woman he loves. Ciccio learns that Tracy has returned to Rome. She can't resist: he goes to see her at the stables!

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

The double wedding of Nonno Libero and Ciccio is upon us and preparations are underway. Maria and Guido have to meet the lawyer for a preliminary interview, to talk about the separation. But will it be the right choice?

Three years have passed since Guido's death, and the time has come for Maria to start over, even sentimentally. Meanwhile Lele asks Bianca to take the plunge, but she discovers that she is still married to her ex-husband.

Bianca is determined to divorce in order to marry Lele, who in the meantime has met an old acquaintance of his, Virginia, in the context of research to cure a rare disease. In addition, problems ahead for Annuccia.

Bianca finds herself fighting on two fronts: seeking information about her ex-husband, and jealousy for Virginia, which grows despite Lele's reassurances. For Maria it's time for an attractive job offer.

Marco announces on the news that the mozzarella of Puglia d.o.p. di Nonna Enrica are produced with different milk and not with buffalo milk. Start the war!

Lele holds a lesson on the environment at Annuccia's school and is very popular among her daughter's classmates. In the meantime, Bianca's ex-husband, to put a spanner in her wheels, is determined to win over her little Inge with all the necessary little tricks.

A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and scared about the future, she finds herself weighing up her ex-husband Gus's offer. Meanwhile, grandmother Enrica plots to bring Maria and Marco closer.

The little ones of the Martini house are victims of bullying at school. When Lele and Bianca discover the situation, they convince the children to report what has happened to the teacher. Bobò will show all the necessary courage.

Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco unmask an illegal gambling den.

Maria, with the help of all her family, takes care of her little Palù and goes back to work in the clinic. Nonno Libero, having left for America, entrusts the task of running the company of Apulian food products to Nonna Enrica.

A hot air balloon ride offered by Gus turns into a cauldron of tensions. Lele joins them as soon as she can, just in time to see the engagement ring she gave Bianca fall down.

Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: in fact, she has taken a homeless person under her protective wing who leaves the whole family stunned.

The Martini Christmas dinner is, as always, a sea port. And this year, on the day when everyone is kinder, Lele will give Gus a break.

Lele, due to the presentation of the research for the drug he is working on, spends more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor.

Maria feels guilty for not having dedicated enough time to Marco lately. But when she shows up at her house by surprise, she'll be the one to be left speechless.

For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.

Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he would like to propose a TV format.

Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.

An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.

Between Maria and Marco everything goes swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce with Gus at a crucial moment in their relationship.

Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.

The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.

Like the rampant baron, Inge decides to run away from home, just on the day when Bianca is busy preparing a birthday cake for Maria. The searches begin.

The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.

At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.

The big day has arrived, and everyone is ready to reach Ovindoli where Lele and Bianca's wedding will take place. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Nonno Libero has finally returned to Poggio Fiorito. Immediately, Marco and Maria announce their marriage, which will take place in two weeks. For the occasion, the grandfather has a special surprise in store: to hire Al Bano!

The proposal to buy the Aurora clinic forces Lele to tell the truth about the house they are about to take from him. The Martini family, informed, takes action.

For the Martinis the situation is critical. Really risking losing the house, grandfather Libero goes on the trail of the builder who cheated them.

For grandfather Libero, the loss of the house is such a serious threat that it even interferes with his own health. After his reluctance to sell used items at the neighborhood market, the family convinces him that everything is fine.

Lele finds herself clandestinely treating an old patient of hers. With great risk, she decides to start visiting clandestinely those patients who cannot adjust to the too high prices of the Clinic.

Annuccia starts the part-time job of pony express in order not to ask her father Lele for money for the international class trip. She finds herself in a seedy neighborhood when thugs harass her.

Relations between Bianca and her mother worsen under the sorry eyes of Inge, who is really fond of her grandmother. Meanwhile Marco lies to Maria about the new assignment he has received.

As if they weren't troubled enough already, the Martinis have to re-roof their house. It's not exactly the right time economically, and the family is really worried.

Lele and Bianca discuss it and believe it is necessary to fire the gardener, who has been tending the garden of the villa for years, but Melina, overhearing the conversation, believes that she will be fired. So she immediately gets busy.

Marco returns to Rome and Maria picks him up at the airport. Unexpectedly, his colleague Antonia is also with him. Lying once again to her girlfriend, Marco manages to get away with a lie, but Maria begins to suspect.

Lele and Bianca discuss the future of the Martini house and therefore decide to look for new accommodation. However, the news is not well received by the children, who decide to occupy the house, without the knowledge of the whole family.

Marco gives Maria the engagement ring, and promises her that they will get married immediately after her last departure for Brussels. Meanwhile at Villa Aurora, Lele and Guenda seem to get closer, after she shows the human side of her.

Maria has no idea where Marco is and therefore takes it upon herself to authorize the operation on little Jonathan. She discovers the bitter truth: Marco lied to her, continuing to shoot documentaries in war zones.

Marco returns to Rome and Maria is waiting for him at the airport, but only to inform him that it is definitely over between them. Both back home, the situation seems to improve: but how long will it last?

Between Marco and Maria it seems to get worse and worse, so much so that he goes home early in the morning to make the children believe that he still lives with them. Nonno Libero notices the situation and promises to help him.

Inge, seeing her father increasingly sad, decides to arrange a meeting with the estranged mother of a schoolmate of hers. However, the appointment falls apart and the woman suffers from anaphylactic shock.

Maria seems more than ever willing to embark on a relationship with Roberto, however continuing to hide everything from Marco, who begins to suspect.

The story between Maria and Roberto seems to continue at its best, but when she discovers that Palù has bitten her friend, showing an aggressive attitude that had never been shown before, she understands that the little girl is suffering.

Marco is in danger of losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated in this way, because now Marco and Maria are forced to organize a fake wedding.

Marco and Maria with the help of the family manage to convince the assistant. Everything could be resolved, were it not for the fact that Micol threatens them: if the wedding doesn't take place, she will do everything to get the baby back.

Marco and Maria announce to their children that when the two return from the camp organized by the school, each will go his own way. At this point Maria can devote herself to Roberto and introduce him to the family.

While Maria is in the car to join her daughter at the campsite, her car breaks down. So she decides to call Roberto, but just at that moment Marco arrives and offers to accompany her.

Lele helps Maria clear her head and the young woman understands that her heart actually beats for Marco. Unfortunately Roberto's father is on the brink of bankruptcy and Maria doesn't feel like leaving him now.

Antonia does everything to distance the journalist from his ex-girlfriend to the point of making Maria believe that, in addition to moving to New York City, Marco is going to live there with her.

Everything seems to turn out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's broadcast, while Maria, after having clarified her doubts, will go back to Marco. And Roberto?

As they are about to cut off electricity and gas at the Martini house, the family decides to leave before everything ends before their eyes. But there's still time to plan a surprise wedding for Maria.