A pushy, abrasive man literally drives into the E.R. to get help for his wife; Ehrlich finds an unusual girlfriend at the laundromat; Fiscus loses both Cathy and Shirley; Dr. Craig clashes with the newly appointed city comptroller, Joan Halloran, over his proposed heart transplant for schoolteacher Eve Leighton.

Medical student Elliot Axelrod and plastic surgeon Dr. Bobby Caldwell join the staff; Eve Leighton's sister expresses reservations about the planned transplant; a resident dropped from the hospital program badgers Cavanero to reevaluate him; and Dr. Craig enlists Dr. Caldwell's help in opposing Joan Halloran's plan to shut down an outpatient surgery clinic.

The men attend a rather staid bachelor party for Kochar; White learns about the dangers of nuclear medicine; Fran Singleton refuses to see her husband, but later walks out of the hospital by his side; everyone opposes Joan's idea of including St. Eligius in a government nuclear disaster contingency plan; Martin gives Kochar a unique wedding present; and the transplant team goes into action.

Dr. Craig performs the transplant amidst a publicity barrage; Morrison tries to adjust to his loss; Luther and Fiscus split an investment in silver futures; and Rosenthal counsels a group on breast cancer.

Dr. Craig and Ehrlich both prepare turkeys for the staff forced to work the holiday; injuries from the Thanksgiving Day parade pour into the ER; and a depressed Dr. Auschlander takes a special interest in an ailing 11-year-old.

Rosenthal gets arrested just before her scheduled breast reconstruction; Mr. Entertainment sets up in a hospital elevator and meets Dr. Ridley, the new psychiatrist; and Morrison worries over an Irish teenager whose near-fatal beating brings the Catholic-Protestant conflict of northern Ireland to St. Eligius.

Martin decides she's in love with Dr. Craig; White regrets helping out an exhausted mother pleading for sedatives in the E.R.; Eve's sense of cabin fever and anger is calmed by a visit from her students; Morrison learns more about Eddie Carson and the `Troubles'.

Dr. Caldwell suffers for his work on Eddie Carson; Joan reveals a secret in the E.R.; Ehrlich meets a brand-new Roberta; Dr. Westphall's housekeeper announces she's returning to Italy; Eve Leighton takes a turn for the worse.

Dr. Fiscus is shot. Afterwards, he experiences the afterlife and meets some old friends. Such people include old patients who died in the hospital, a few in limbo and a couple in heaven. However, he is condemed to hades and finds Dr. White swiming in circles for all eternity in a boat with only one oar.

Meamwhile, the docs at St. Eligus try their hardest to keep Fiscus alive.