Wedding bells are set to ring for PC Penhale and Janice, but nothing ever goes smoothly in Portwenn.

Martin and Louisa search for a nursery now that Janice has left, and Mrs Tishell is shocked to find out that Al has very high blood pressure. Louisa also helps with the diagnosis of a pupil, which spurs her on to explore the possibilities of a change of career. This is not welcome news for Martin, who dislikes any kind of change, even if it could be for the better. Elsewhere, Ruth is approached about selling her farm.

Martin is left holding the baby when Louisa has to take Year Six pupils sailing. He has to collect James from nursery every afternoon, but with surgery hours Martin is constantly late.

Morwenna’s parents Jack and Tara pay a surprise visit, having been working as missionaries in Kenya. However, the reunion is tinged with sadness when it turns out that Morwenna’s mother has liver cancer, and has decided against treatment because of her faith. Louisa’s first online call for her new course does not go as planned – especially when Martin tells the lecturer exactly what he thinks – and Joe investigates a break-in at the school where nothing has been stolen. Martin Clunes stars in the comedy drama, with Jessica Ransom, Caroline Catz, John Marquez, Kevin Doyle and Rebecca Lacey.

Louisa has problems at school with Toby, Angela Sim’s Nephew. Meanwhile, Al has a ‘Large Whiskey’ order and has to ask Bert for some help, and Mrs Tishell seems to be having a delayed onset of mourning. Elsewhere, Martin and Louisa decide to try Mel’s suggestions of using amber beads to help James while he is teething.

Penhale decides to have a Police Open day to raise community awareness, but the only genuine visitor is an angry farmer who has had three of her sheep stolen. Meanwhile, Morwenna decides to take Al away for the weekend to try out Hannah’s new glamping site, but the trip does not go well as Al accidently burns down the yurt. Elsewhere, James has started biting not only Louisa but other children at the nursery. Louisa speaks to Tina about it, but is surprised to find out Tina has spoken to their lecturer about it too.

Martin wakes up to an empty bed. When he goes looking for Louisa he discovers she is trying to write her resignation letter.

Martin prepares to face his hearing, but despite having closed the practice, he finds all his patients are trying to make appointments. An American tourist who visited Portwenn previously returns to the town, hoping to research her family tree. However, she also has a medical issue, and comes to the troubled doctor seeking his advice. Louisa goes to see Chris to find out how serious the situation is, while the townsfolk take steps to show Martin how much he is appreciated.

Martin's medical career remains under scrutiny, as a GMC representative has come to assess him and his surgery.

Martin's GMC report requires he passes three refresher courses which will then decide whether he is deemed fit to practice, starting with phlebotomy.

Ruth is concerned about becoming increasingly forgetful, and is even more perturbed when Martin offers to perform a mini mental state examination.

Martin has his second GMC assessment - mock surgery - and Buddy is missing. Meanwhile, Ken's arrival does not bring good news for Al and Bert, and Penhale unhappy with the arrival of his predecessor, Mark Mylow, who tries to take charge of his investigation.

Martin investigates after local farmer Dennis Thorpe shoots at Robert for taking some of his eggs. Meanwhile, Emily returns to the surgery to see Martin after her acne medication caused a bad reaction, a secret bidder buys the Crab and Lobster pub, and Louisa ponders if she should see a fertility specialist.

Martin and Louisa have their first fertility consultation with Dr Emma Ryder. Meanwhile, a case of vandalism at a local surf school is reported and PC Joe Penhale investigates. Elsewhere, Dr Edward Mullen returns to the surgery, and Bert is feeling the pressure from Caitlin. Starring Martin Clunes, Lucy Russell and Conleth Hill.

Martin has to rush Buddy the dog to the vets. Meanwhile, Mrs Tishell's young cousin Sarah joins her for some work experience, but it does not go to plan, and one of Louisa's clients arrives at the surgery unannounced, posing a dilemma.

Martin rushes to Ruth's for a medical emergency, and preparations for Morwenna and Al's wedding do not go to plan. Elsewhere, Martin takes his final GMC assessment under the watchful eye of eminent surgeon Bernard Newton, who monitors Martin's skills in assisted surgery.