Today is the first day of the rest of Earl Hickey's life. After coming into a $100,000 scratch-off lottery ticket and losing it just as fast upon being hit by a car, Earl has an epiphany in the hospital--to make up for all the terrible things he's done in the past. With his brother Randy and a motel maid named Catalina, Earl writes up a list of every misdeed he was a part of. Earl sets out to do just that, starting with #64--Kenny James, a boy he picked on in elementary school.

Earl must make amends to Donny, an intimidating thug who spent two years in jail for a robbery Earl committed. Oddly enough, the only way he can do this is by helping Donny's mom quit smoking. Meanwhile, Joy discovers she's the beneficiary of Earl's will and decides to kill him!

Back in their high school days, Earl ruined Randy's chance to score a touchdown during a key football game; now Earl must figure out a way to make things right.

In order to replace a fancy figurine that he broke, Earl lends a hand to help Joy's former adversary and her daughter win a mother/daughter beauty pageant . However, Joy enters the pageant also with her "dead" mother trying to win that same figurine, hoping to trade it for a hot tub.

Earl attempts to help Scott get over his preoccupation with golf--an obsession caused when he and Randy started fixing Scott’s golf game to get free beer. But after becoming so thoroughly entangled in Scott’s personal life that he drives Randy away, Earl realizes that he may be the one with the obsession.