Dave has to deal with mood swings and PMS when Vicky and Hillary's menstrual cycles start in full swing. So, when a reluctant Dave has to take Hillary to the gynecologist's office, he soon discovers that Dr. Vogel is his old best friend, who happened to be a ladies' man in high school. This leads to the doctor's professional relationship with the family getting personal since Dave doesn't believe he's changed his ways. Meanwhile, Larry tries to do whatever it takes to gain the respect of Mike when he calls him a nobody.

Dave thinks he's still a catch for the ladies when he gets hit on by an attractive saleswoman at work. But he soon learns that she was only checking him out for her mother. Meanwhile, Vicky attracts guys of all ages when she goes to Mike's class for Career Day. And back home, Hillary gets attracted to Kenny's sensitive side.