Cruella has a family reunion so they can figure out on ways to get the Dearlys farm.

Cadpig and Mooch fall in love, although Cadpig's only aim is to persuade him not to fight in a wrestling match against El Diablo. However, despite Cadpig's controlling of him, Lucky, Rolly, and Spot want him to fight, and attempt to help him get up to shape for the fight.

Spot wishes she was a dog. Drumstick, her fairy god-chicken, shows up to grant her wish. Soon, however, Spot gets more than she bargained for when she discovers that being a dog has many disadvantages.

A) P.H. DeVil splits Cruella's good side into a clone meant to improve her image.

While Pongo, Perdita, and the humans are away, Cadpig discovers she has PDS, and Swamp Rat takes over the house for his party. The pups, with Lt. Pug, try to drive him out.

Roger plans a second honeymoon trip for him & Anita to renew their wedding vows. But the Dearlys wind up taking the 101 dalmatians and then Cruella along with them or Anita will be fired. Then Roger and Anita find out they aren't married.

Cruella finds out that she can steal the farm away from the Dearlys if they don't get married in 48 hours. So Cruella comes up with stunts to keep them from getting to the church in time. Including tricking Roger into signing a contract to play baseball.

The pups try their best to help Roger find Anita, who is held captive by alien cultists who refuse to let her leave until their Shaggy-Green Messenger comes for them.