After suffering a heart attack, Andy tells a young pregnant woman that in order to save her and her unborn child she must get a heart transplant. However, unexpected complications with the donor's family place the transplant in jeopardy.

An 18-year old in need of a double-lung transplant, struggles to survive as the team runs into an obstacle that may prevent her from being eligible for the procedure.

Andy and Sophia treat a car crash victim named Victor dying from ALS who asks to be to taken off of life support so his organs can be used to save others. Meanwhile, David tends to a foster parent with pulmonary hypertension who refuses admission to the hospital.