Live from New York, it's... Amy Adams!

Sketches include "Clinton Attack Ad," "Mirror Image," "Green Card Couple Therapy," "A New Superhero" (Digital Short), "Fierce: The Hot Mess Makeover Show," "Penelope in Driving " "Dr. Uncle Jimmy's," "Roger Clemens Presents," "The Best of the Tookie Stiles Show," and "Dancing Galpals."

Vampire Weekend performed "A-Punk" and "M79."

Actor Zach Galifianakis hosts; Vampire Weekend performs "Cousins" and "Giving Up the Gun."

Sketches include "Health Care Reform," "The Vogelchecks," "Bidet," "Zach Drops by the Set," "Today," "Weekend Update" with guests Mo'Nique and Will Forte, "What Up with That?" "The Situation Room," and "Pageant Talk."

Host Kristen Wiig; Vampire Weekend perform.