Secret Service agents Lattimer and Bering are "rewarded" with a transfer to the top-secret Warehouse 13. They meet Artie Nielsen, the caretaker of the mysterious warehouse, who tells them about their new job. The agents are responsible for the collection of every supernatural and unexplained item that the U.S. Government has ever collected. For their first assignment, they are sent to Iowa to investigate a possible artifact belonging to a college student who went berserk and assaulted his girlfriend while chanting an Italian incantation.

A woman kidnaps Artie and insists that he help her recover her brother... who was lost in an artifact-related experiment 12 years ago.

The team tries to track down their rogue member, and discover the artifact they have is unexpectedly powerful. Meanwhile, Claudia wonders about her future with the Warehouse team and Pete must choose between Kelly and the mission.

When we last left agents Myka Bering and Pete Lattimer at the conclusion of season 2, Myka had decided to leave the top secret team with little to no warning. As season 3 begins, Artie fills Myka's shoes with 'The New Guy,' which also happens to be the name of the season premiere episode.