A returnee exhibiting telepathic abilities seeks help from NTAC, but is instead used as a mole to infiltrate Jordan Collier's 4400 Center.

Tom and Diana investigate a 4400 whose ability to increase the human bodies' metabolism just may be this weight-conscious world's answer to the ultimate fat-burner.

A morbid premonition from Maia threatens the future of the 4400 Center.

After living for 8 years in an alternate world that only Tom and Alana remember the world with the 4400 has returned as it was at the second the 8 years started. A 30 year old 4400 woman wakes up and finds everybody else in her local community dead. Maia puts April's love for her to a test.

A 4400 with the ability to repair damaged chromosomes hides a shocking past. And while Richard seeks out a tormentor among his Korean War buddies, Shawn reconnects with his family and tries to help Kyle.

NTAC and the 4400 Center work together to find Jordan Collier. Kyle Baldwin gets a surprising visitor at the state prison.

NOVA group members that were in the custody of NTAC escape from jail with outside help from Jordan Collier. Diana tells April about her relationship with Ben. Shawn and Richard learn that Isabelle is working with Dennis Ryland.

Tom and Diana continue their investigation on Jordan Collier's plan for mankind. Dennis Ryland rejoins NTAC. Isabelle prepares for battle.

Diana locates her sister, April, who took promicin and developed an ability that puts her life in jeopardy.