Dopo essere stati rifiutati da alcune ragazze per la richiesta di venire al ballo di fine anno, Steve e Snot decidono di usare la macchina della clonazione della CIA per inserirvi dei campioni di DNA presi da due ragazze, ma una volta fatto ciò dalla macchina escono fuori delle neonate in rapida crescita.

La casa degli Smith è infestata da quello che si presume essere lo spettro sessuale insoddisfatto di Francine e, per cercare di eliminarlo, la famiglia viene aiutata da una medium di nome Ruby Zeldastein (un altro dei tanti travestimenti di Roger). Nel frattempo Klaus va in vacanza ad Atlantic City per un seminario, ma quando si trova in camera subito dopo aver acceso il televisore con un messaggio promozionale dell'hotel ripetitivo, Klaus, intento a prendere il telecomando, si spezza la schiena ed è costretto a rimanere bloccato per l'intero soggiorno.

In a desperate attempt to show Steve that she's still a "cool" mom, Francine teaches him a vast array of shoplifting techniques to try out at the local mall. B when their attempt to pull off the ultimate heist at "The Gash" goes awry, Steve is captured and sent to a Venezuelan sweatshop. Meanwhile, Roger, Hayley and Klaus form Langley Falls' first Russian Balalaika trio.

Stan's plans for a perfect Thanksgiving watching football in his underwear are thwarted when Francine invites her adoptive parents to join them for the holiday.

Determined to get Snot to confront his emotions after his father passes away, Steve and friends embark on an epic cross-country road trip to the funeral. But Steve's commitment to his friend wavers when he falls for a Pixie Dream Girl along the way. Meanwhile, Stan and Roger invent an automatic cake-cutter for the Home Shopping Network, but their partnership is tested when they only make a "verbal agreement" to split the profits.

In this “Breaking Bad” parody, Hayley tries to fit in with a popular group of her former high school friends and, in the process, discovers Steve has an amazing ability to create incredibly realistic fake IDs. Sensing a business opportunity, Hayley builds out Steve’s operation, but they don’t count on having to deal with the other kingpin of the Langley Falls fake ID game: Kevin Ramage (Roger in disguise).

When Steve starts acting like a spoiled brat during the holidays, Stan takes him to see his incarcerated Grandpa Jack, who tells him the story of how he caught Minstrel Krampus, a legendary demon who punishes naughty children on Christmas. Stan decides that releasing Krampus is the only way to straighten out Steve's attitude. But when Krampus kidnaps Steve, it's up to Stan and Roger to get him back. Meanwhile, Hayley gets a job at the airport, but quickly realizes that she might not be cut out for customer service.

Roger suffers a horrific car crash as he tries to take a picture of his crotch on a traffic speed cam. After waking up from a coma, he starts to have eerie visions of the future, and saves the Smiths from a terrible fire. But, Roger's abuse of his newfound powers soon draws the ire of his fellow family members and the Smiths must learn to cope with the uncertainty of the future.

Francine tries to relive the Smith kids' childhood by taking a group trip to the "Familyland" theme park that ends up being anything but family-friendly.

Stan mixes up his nighttime routine after his 100th kill, but mistakenly unleashes a "good" Stan in his sleep - Jekyll & Hyde-style - who's hell-bent on pursuing all the good deeds that real Stan would never consider, and stopping him from ever killing again.

Roger forges a radical plan to help Steve date the hot girl at school. Roger will switch faces with Steve "Face/Off"-style, seduce her, then tag Steve back in after she's fallen for him. But, Roger soon decides he may actually want to keep her for himself. Meanwhile, Stan and Francine become "Charlie's Angels"-type airline stewardesses to thwart an evil plan by Mark Cuban who wants to blow up the sun.

Stan is frustrated that Steve and his friends never play outside, but Francine refuses to let Stan take the kids to the woods for some outdoor fun. Of course, Stan finds a loophole, by drugging the kids and putting them on the CIA's holodeck, which, naturally, goes awry. Meanwhile, Hayley buys Roger's home star on the International Star Registry and claims she's now his queen.

Stan tries an experimental pill from the CIA and turns into a girl. Meanwhile, Klaus and Roger start a business selling Stan's suits as he no longer needs them as a female.

Stan attempts to infiltrate the "Occupy" movement, based on CIA intelligence that a leftist cell is planning a terrorist attack. But when he's captured and returned home by a group of radicals, Hayley suspects her father may have been "turned".

Stan fears that Hayley has no life skills so he forces her to take a job as a bartender in Roger's attic bar but, when Bullock becomes Hayley's best customer, Stan realizes that he can use his daughter's knowledge to get ahead at work.

Stan's co-workers at the CIA teach him about "rubbernecking," the art of checking out other women on the sly, away from the gaze of their wives. But when Stan causes a massive accident in an attempt to take a picture of an attractive jogger, he's interviewed by an intimidating insurance inspector who may rat out Stan to Francine. Meanwhile, Roger and Klaus spill wine on the Smiths' brand new couch, and vow never to tell the other family members by sitting on the stained spot for the rest of their lives.

Stan is fired from the CIA in a round of budget cuts, but since his 20 years of work experience are classified and hidden from his "permanent record", the only job he's able to land is at the local grocery store where Steve is the manager. Meanwhile, Roger bets an annoying coffee shop musician that he can outplay him in one week. To accomplish his goal, he enters into a Faustian bargain with Lorenzo, a guitar-instructing infomercial host.

Hayley starts an internship at a local news station working for a Nancy Grace-type reporter, who happens to be Roger in disguise.

Hayley, still heartbroken over Jeff’s abduction, meets millionaire Matt Davis, who begins to help her move forward, until Steve and Snot discover that Jeff’s alive and trying to make it back to her.