As Chuck and Sarah try to realize a new, safer future, Morgan’s past as the Intersect sends them to Vail on one last mission, where they enlist the help of an unlikely source — the legendary Bo Derek. Elsewhere, Jeff and Lester continue their own spy mission.

When a mission in Japan becomes a hostage situation, Sarah and Chuck must face the merciless Nicholas Quinn aboard a speeding Japanese bullet train. Meanwhile, the mission leaves Casey with an impossible decision.

After a harrowing mission, Sarah returns to Chuck with a huge secret. Meanwhile, Ellie and Awesome are presented with a new opportunity that could change their lives.

Chuck enlists his family, friend and some unexpected allies as he races to stop Nicholas Quinn from destroying everything Chuck has built over the past five years.