Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.

Coulson and his team race to combat Hive's control over the Inhumans, as their enemy's deadly plan for the human race is revealed.