The St. Louis Cardinals make a run for the title with the help of sluggers Larry Walker and Albert Pujols. The Minnesota Twins see the rise of ace pitcher Johan Santana. The Boston Red Sox attempt to shake off the memories of their defeat the previous year at the hands of the Aaron Boone and the New York Yankees. They get their chance when the two get a rematch, resulting in the greatest comeback in the history of the game. The Red Sox meet the Cardinals in the World Series.