Just when the first Godzilla is destroyed, another one is born. Imprinting on Dr. Nick Tatopoulos, the infant eludes the military then follows Nick to his waterfront headquarters.

In the wake of Godzilla’s apparent death, Nick convinces H.E.A.T. to stay together to study other mutations around the world. The team travels to Jamaica to investigate attacks on boats and swimmers from what appears to be a giant squid.

A new form of microorganism is created, designed via genetic engineering to consume oil spills and other manmade pollutants in New York City but it mutates and becomes an enormous, ever-growing mass of protoplasm that devours everything in its path.

A colony of huge mutant rats appear on the scene, wreaking havoc on the sprawling metropolis at night. Soon, the problem is escalated as Godzilla appears and begins to attack the rats in defense of his territory, thus causing more destruction to the city.

Yet another scientific research team disappears, this time in the South Pole [geez, these research teams are a royal pain in the posterior, but what would sci-fi and horror series and films ever do without them!], and yet again, H.E.A.T. travels there to investigate, suspecting a creature problem again [just think of all the work that H.E.A.T. would miss if not for vanishing research teams!].

Tatopoulos discovers that Godzilla is undergoing unusual changes, growing physically smaller, and also acting nastier and less subject to his control. Upon further investigation, he discovers that the source may be related to reports of giant mutant termites in the Amazon Rain Forest. Upon traveling there, Randy concocts a device that emanates audio signals of a specific frequency, which creates mass confusion among the termite colony. As a result of this, Godzilla returns to normal.

Shady promoter Maximillian Spiel entertains wealthy ticket holders with a series of “cage matches” between giant mutations like the Shrewster and the Giant Centipede. For his next bout, Spiel sets his sights on the “ultimate monster”… Godzilla.

In Miami, Godzilla, H.E.A.T., and Major Hicks battle Skeetera, a mutated bloodsucking mosquito-like insect who adapts the powers of the creatures she feeds on. As they attempt to contain the creature they are interrupted by the mutation rights fringe group known as S.C.A.L.E. (Servants of Creatures Arriving Late to Earth).

While on a romantic cruise in Alaska, Nick and Audrey’s ship is attacked by a Giant Turtle.