Clarice is drugged and confined to a hospital bed by a serial killer in the medical profession, causing her to experience intense hallucinations.

Sidelined because of her harrowing ordeal with Marilyn Felker, Clarice goes to Ruth Martin to be reinstated and gets roped into having dinner at the Martin residence.

Clarice and Ardelia team up to investigate a deeply twisted cold case after the body of a missing teenager is found entombed in concrete. Also, Clarice wrestles with the knowledge that Krendler may know the man who attacked her while she was held captive.

Clarice feels an emotional tie to the victim when ViCAP investigates what appears to be the suicide of a medical student in the United States on a foreign visa. Also, Krendler secretly collects a DNA sample from the man he suspects attacked Clarice at Woodhaven.

After ViCAP links the River Murders to a pharmaceutical company, Clarice seeks help from Julia Lawson, the corporate accountant for the company, who refuses to work with the FBI, and with Clarice specifically. Also, Catherine goes outside for the first time since her rescue from Buffalo Bill, and Ardelia and Agent Garrett connect with a lawyer they hope will take on the Black Coalition's case against the FBI.

Clarice zeroes in on the entity behind the River Murders, Alastor Pharmaceuticals. When Julia informs ViCAP of the impending sale of the company, ViCAP rushes to Alastor to prevent the purging of any incriminating evidence. Also, Clarice questions Alastor CEO Nils Hagen, who quickly changes the subject to Clarice’s relationship with his son, Tyson.

As ViCAP finally gets the green light to raid Alastor Pharmaceuticals, Clarice punches another FBI agent in a moment of rage, then willingly turns in her badge and gun. Also, the rest of the ViCAP team uncovers the whole truth about the River Murders, and Clarice unwittingly puts herself in mortal danger.