In the surgical department of Holby City Hospital, surgeons Anton Meyer and Nick Jordan race against time to carry out a heart transplant operation, but first they have to make the difficult choice between two possible recipients, Alan Kenyon and Simon Harwood.

Nurses Julie Fitzjohn and Jasmine Hopkins vie for the post of Deputy Ward Sister.

Kirstie Collins, who is helping Muriel McKendrick with the trial of a new drug, finds a severe adverse reaction from a patient, and wants to alert the drugs company, but McKendrick warns her against doing so.

The staff of Darwin Ward, the cardiology ward, struggle to stop the spread of the life-threatening MRSA infection; suspicion about its origin falls on Nurse Julie Fitzjohn.

There's gossip about Nick Jordan and Karen Newburn.