2003. As a parasitic fungal outbreak begins to ravage the country and the world, Joel Miller attempts to escape the escalating chaos with his daughter and brother. Twenty years later, a now hardened Joel and his partner Tess fight to survive under a totalitarian regime, while the insurgent Fireflies harbor a teenage girl with a unique gift.

As Joel fights to survive, Ellie’s struggle to save him stirs memories of her life in a FEDRA orphanage. Weeks before meeting Joel, Ellie recalls joining her best friend Riley for a night to remember… one that will change the course of both of their lives – and the fate of the world – forever.

After being pursued by Infected, a pregnant Anna places her trust in a lifelong friend. Years later, Ellie is forced to grapple with the emotional toll of her journey, while Joel faces a devastating decision of his own.