An ambitious anthology film featuring segments directed by over two dozen of the world's leading talents in contemporary genre film. Inspired by children's educational ABC books, the film comprises 26 individual chapters, each helmed by a different director assigned a letter of the alphabet. The directors were then given free reign in choosing a word to create a story involving death.

The special takes place during the two year before the Straw Hats reunite on Sabody. Luffy is currently in Rusukaina training to get stronger to take on the New World. However the training is interrupted when Hancock's sisters, Marigold and Sandersonia, are kidnapped by the Byrnndi World, a pirate who was locked away on Level 6 of Impel Down but escaped during Luffy's invasion to save Ace, in order to lure Hancock to him and use her as a hostage against the World Government due to her Shichibukai status. Thus Luffy and Hancock head off to confront him and save Hancock's sisters.

This is NOT ABCs of Death 3. ABCs of Death 2.5 showcases an additional top 26 finalists, providing fans 85 minutes of unadulterated madness.

Taking all that was great from the first instalment, the movie aims to be a wilder, leaner, faster-paced and even more entertaining anthology this time around, with a new crop of award-winning, visionary filmmakers from around the globe.