Stuart, an adorable white mouse, still lives happily with his adoptive family, the Littles, on the east side of Manhattan's Central Park. More crazy mouse adventures are in store as Stuart, his human brother, George, and their mischievous cat, Snowbell, set out to rescue a friend.

One day during summer vacation, a palm-sized alien named Papi appears from a small rocket that Nobita picks up. He is the president of Pirika, a small planet in outer space, and has come to Earth to escape the rebels. Doraemon and his friends are puzzled by Papi’s small size, but as they play together using the secret tool “Small Light”, they gradually become friends. However, a whale-shaped space battleship comes to earth and attacks Doraemon, Nobita and the others in order to capture Papi. Feeling responsible for getting everyone involved, Papi tries to stand up to the rebels. Doraemon and his friends leave for the planet Pirika to protect their dear friend and his home.

Deputy Sheriff Joe "Deke" Deacon joins forces with Sgt. Jim Baxter to search for a serial killer who's terrorizing Los Angeles. As they track the culprit, Baxter is unaware that the investigation is dredging up echoes of Deke's past, uncovering disturbing secrets that could threaten more than his case.