This film tells the tale of the Harper Affair, in which young Jimmy Harper finds his life of promise turn into a life of debauchery and murder thanks to the new drug menace marijuana. Along the way he receives help from his girlfriend Mary and Jesus himself, but always finds himself in the arms of the Reefer Man and the rest of the denizens of the Reefer Den.

In RiffTrax Live: Reefer Madness, Mike, Kevin and Bill deliver their trademark form of rapid fire comedy in front of a live audience! Lines could be flubbed! Tomatoes could be thrown! Mountain lion attacks are entirely possible!

With free eyes, an open heart, good friends and a handful of luck, Gurcius Gewdner revisits some of his adventures of the past five years, survives the relentless Russian winter and asks the following question: How far can an underground Brazilian film go?

"It's all a LIE!!" or so screams our hero, DETECTIVE JACK PERRY. We meet Jack in the prologue as he interrupts a telecast of a movie review program. He claims REEFER MADNESS, the classic cult film which the two critics are reviewing, is nothing but a slanderous lie. We have been shown clips of the original film where Perry was portrayed as a low-life drug pusher. Now, here it is, decades after REEFER MADNESS was first released, and the real life Jack Perry shows up and claims, "...the movie was made to frame me. I was actually an undercover cop!" The two critics don't buy any of his story. Jack says he can prove what he claims by showing his version of the movie -- which he just happens to have brought along. The reviewers tell Jack that they don't have time to show his film on their program. Jack's 44 Magnum convinces them otherwise.

A punk rocker and his girlfriend sneak into a cemetery at night for some graveyard sex, but they are interrupted by the Grim Reaper.

High-school principal Dr. Alfred Carroll relates to an audience of parents that marijuana can have devastating effects on teens: a drug supplier entices several restless teens, Mary and Jimmy Lane, sister and brother, and Bill, Mary's boyfriend, into frequenting a reefer house. Gradually, Bill and Jimmy are drawn into smoking dope, which affects their family lives.

When an evil alien bong crashes on Earth, Luann, Larnell and their other pals soon discover its evil intent: full-blown global domination!