A poet falls in love with an art student, who gravitates to his bohemian lifestyle — and his love of heroin. Hooked as much on one another as they are on the drug, their relationship alternates between states of oblivion, self-destruction, and despair.

An aimless adolescent joins several itinerant misfits who live on the fringe of society and welcome at-risk youths into their fold.

Blaise and Nessa are outcast methadone users in their small town. Each day they push a rusty lawnmower door-to-door begging to cut grass. Nessa plots an escape, while Blaise lingers closer to collapse. Tethered to one another, their getaway dreams are kept on a suffocatingly short leash.

Shot over the course of 18 months in New York City's Lower East Side, METHADONIA sheds light on the inherent flaws of legal methadone treatments for heroin addiction by profiling eight addicts, in various stages of recovery and relapse, who attend the New York Center for Addiction Treatment Services (NYCATS).