Cincuenta desconocidos se despiertan encarcelados juntos dentro de una cámara misteriosa formando un círculo. En tiempo real, deben identificar a sus captores y decidir cuál de ellos merece sobrevivir, en un juego macabro que nadie sabe cómo puede terminar.

Cuando Kassie (Jennifer Aniston) cumple los cuarenta decide no esperar más y recurre a la inseminación artificial para tener un bebé. Siete años más tarde, regresa a Nueva York y se reencuentra con su amigo Wally (Bateman), un hombre neurótico e inseguro, que, de manera inexplicable se siente fuertemente vinculado al hijo de Kassie, el pequeño Sebastian (Thomas Robinson), un niño con el que comparte algo más que sus múltiples manías y excentricidades. Basada en el relato "Baster", del novelista ganador del premio Pulitzer Jeffrey Eugenides, autor de "Las vírgenes suicidas".

Jane Ravenson finds herself in the middle of a grocery store with $10,000 in her coat pockets and no memory of her life or who she is. Her husband eventually finds her and she starts to believe that her family life is fine until she feels a deep, nightmarish paranoia that something is horribly and terribly wrong.

John is a brilliant linguistic scientist with a loving wife and daughter but with a massive gap in his life. Eight years ago, he turned up out of nowhere, with no memories except a recurring dream. He is sent tumbling down the proverbial rabbit hole after meeting a man that shares a similar condition and learning that there are more like him, all amnesiacs with extraordinary abilities. He convinces his brother-in-law, private investigator Carl, to help him uncover his true identity before his past can rise up to destroy him and his family.

Alyssa wakes up in a home that's not hers and discovers a dead body. With no memory of how she got there, and no idea of who he is, Alyssa tries to piece together what exactly happened the night before.