Dizi, insan cinselliğinin öncülerinden Masters ve Johnson'ın sıra dışı yaşamlarına, çalışmalarına ve araştırmalarının ateşlediği devrime ışık tutuyor.

Relationship coach Marin Frist knows what to look for, what to avoid and what will make her happy. As the many fans of her two bestselling books could tell you, we're all in charge of our own happiness. But like many people full of advice, she fails to apply it to herself. On her way to a speaking engagement in Alaska, she learns that her fiancé has cheated on her. Slapped in the face with personal failure, a snowstorm then leaves her stuck in a small town full of the one thing she really doesn't need—available men.

Takes place twenty years after the events of “L’Auberge Espanole,” and follows Tom and Mia, the children of the film’s protagonists Xavier and Wendy, as they spend time in Athens.