Jaime goes undercover with a deadly human trafficking ring. Danny and Baez investigate a homicide connected to Darryl Reid, Danny's old partner. Also, Frank grapples with whether to publicly support Mayor Chase on a policy decision and Eddie is determined to teach a young shoplifter a lesson.

Danny and Baez join forces with Danny's old partner, Jackie Curatola, when a serial killer reappears. Also, Eddie faces backlash when she tries to help a woman who accuses a sergeant of rape.

Frank grapples with the personal loss of his best friend and how best to help Tess Ross, the daughter of his best friend, when she lands in jail. Also, Jaime and his nephew, Joe Hill, race against the clock to reunite a trafficking victim with her sister; and Danny and Erin clash when she goes behind Danny's back to use his criminal informant in an investigation.

Danny se reencuentra con una adolescente problemática de un caso anterior cuando la joven se encuentra en peligro. Además, Frank se enfrenta a una difícil decisión personal cerca de casa; Jamie empieza a sospechar cuando le piden a Henry que sea entrevistado para una serie web de investigación; y Erin y Anthony investigan cuando Erin es el supuesto objetivo de un tiroteo.

Erin es designada para dirigir una investigación federal sobre las carreras de caballos corruptas. Además, Jamie investiga una operación de tráfico de drogas en la que participan bandas rivales; Danny y Baez investigan una serie de asaltos en Little Vietnam con la ayuda de una cara conocida; y Frank se encuentra dividido cuando se entera de que la Hermandad de Camioneros está presionando para que los agentes de la policía de Nueva York se afilien a su sindicato.

Danny and Baez investigate a homicide involving voodoo with the help of Baez's old partner. Also, Eddie and a fellow officer team up with Captain McNichols when they suspect a prestigious school is employing discriminatory admission practices.

Jamie works to bust a group of scammers who use artificial intelligence to defraud the elderly. Also, Danny and Baez investigate a series of mysterious deaths at a hospital; Anthony is determined to take down an attorney who exploits the law for his own financial gain; and Frank disapproves when he learns Gormley is planning to face off against fellow officers in a "smoker" boxing match.

Danny gets involved when Sean becomes the latest victim in a series of robberies on Sean's college campus. Also, Erin grows suspicious of an overworked attorney who she believes isn't acting in his client's best interest.

Danny and Gormley race to find Gus Vanderlip, a committed detective who is dangerously determined to uncover how a rapist he arrested is back on the streets; on the eve of their anniversary, Jamie and Eddie are sent on an undercover assignment to expose a corrupt sober living house; and Henry asks Frank for a favor regarding the NYPD's 9/11 Victims Compensation Fund.