Charlene's night of romance is interrupted by her older sister Darlene, when she shows up after leaving her husband. Younger sister Marlene later drops by after losing her job as a toll-collector.

Charlene convinces her sisters and her boyfriend to join a health club. After hearing two women make fun of their size, Charlene wants to quit but is too humiliated to tell Marlene, Darlene, and Ronnie why she doesn't want to go back.

Determined to cheer up Darlene, Charlene insists on taking her to the laundramat to find a suitable companion.

Charlene dreads meeting Ronnie's mom. After much convincing, Charlene goes to meet her at a restaurant and manages to insult her before they are even introduced. Determined to make things right, Charlene invites Ronnie's mother over for dinner, only to find that nothing will satisfy her.

Darlene finds it difficult to control her anger when Wilbur demands spousal support.

After almost getting crushed in an accident, the sisters do some soul searching.

When Charlene's interference gets Marlene fired as the Hefty Hose girl, she finds a job on a soap opera. Meanwhile, Darlene dog-sits a seemingly-sweet puppy who turns out to be more than she can handle.

Faced with the dreaded ""eating season"", the sisters decide not to have a Thanksgiving dinnner. After meeting a homeless orphan, they plan a real Thanksgiving dinner for him.